Evidence map›Paper›PMID 40210483›Full record

ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2025

[A Case of Multiple Primary Pulmonary Neuroendocrine Carcinoma
with EML4-ALK Fusion Gene Positive].

Yin Zhang, Yue Hou, Tianming Zhang, Hong Wang

Abstract readCase ReportsEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yin ZhangDepartment of Pulmonary and Critical Care Medicine, Lanzhou University Second Hospital, Lanzhou 730030, China.
Yue HouDepartment of Pulmonary and Critical Care Medicine, Lanzhou University Second Hospital, Lanzhou 730030, China.
Tianming ZhangDepartment of Pulmonary and Critical Care Medicine, Lanzhou University Second Hospital, Lanzhou 730030, China.
Hong WangDepartment of Pulmonary and Critical Care Medicine, Lanzhou University Second Hospital, Lanzhou 730030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine carcinoma (NEC), a subtype of neuroendocrine tumors with high proliferative activity, is characterized by strong invasiveness and poor prognosis. This article reports a previously healthy female non-smoker who developed NEC occurring sequentially in different lobes of both lungs. The lesions were pathologically diagnosed by hematoxylin-eosin (HE) staining as large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC), respectively. Next-generation sequencing (NGS) performed on both lesions revealed the presence of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion mutations in both lesions. Notably, the patient achieved a significant therapeutic response to ALK-tyrosine kinase inhibitors (TKIs) targeted therapy.
.

Indexed as

Carcinoma, NeuroendocrineLung NeoplasmsOncogene Proteins, FusionFemaleHumansMiddle AgedEML4-ALK fusion protein, humanOncogene Proteins, FusionALK mutationLarge cell neuroendocrine carcinoma of the lungLung neoplasmsTargeted therapy

Identifiers

PMID40210483
PMCPMC11986677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.