Evidence map›Paper›PMID 40210434›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)2025

Medial septal theta stimulation enhances spatial working memory performance in rats.

Zachary M Gemzik, Amy L Griffin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zachary M GemzikDepartment of Psychological and Brain Sciences, University of Delaware, Newark, Delaware 19716, USA.ORCID http://orcid.org/0000-0002-4997-3466
Amy L GriffinDepartment of Psychological and Brain Sciences, University of Delaware, Newark, Delaware 19716, USA amygriff@udel.edu.

Funding

Using hippocampal-prefrontal theta synchrony to enhance spatial working memoryR21MH117687 · NIMH · UNIVERSITY OF DELAWARE · PI GRIFFIN, AMY L. · 2019 to 2020
$375k
NIMH NIH HHS R21 MH117687
6 · The paper itself

Abstract

Spatial working memory (SWM) relies on the integrity of the medial septum area (MSA) and its ability to drive theta (4-12 Hz) oscillations in the hippocampus. This study tested the hypothesis that optogenetic theta stimulation of the MSA would enhance choice accuracy on a hippocampus-dependent task in rats. We delivered either excitatory or control theta stimulation during the delay period (10 or 30 sec) of a delayed alternation (DA) task. We show that MSA theta stimulation improved choice accuracy on the 30 sec delay trials, providing strong support for the notion that MSA theta stimulation boosts SWM.

Indexed as

Memory, Short-TermSeptal NucleiSpatial MemoryTheta RhythmAnimalsChoice BehaviorHippocampusMaleOptogeneticsRatsRats, Long-Evans

Identifiers

PMID40210434
PMCPMC12052090

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.