Evidence map›Paper›PMID 40210379›Full record

ReviewNeuroimaging clinics of North America2025

PET Imaging of Neurofluids.

Liangdong Zhou, Yi Li, Mony J de Leon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroimaging clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Liangdong ZhouDepartment of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 E 61st Street Feil-2, New York, NY 10065, USA.
Yi LiDepartment of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 E 61st Street Feil-2, New York, NY 10065, USA.
Mony J de LeonDepartment of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 E 61st Street Feil-2, New York, NY 10065, USA. Electronic address: mdl4001@med.cornell.edu.

Funding

Brain fluid clearance and misfolded protein dynamics following traumatic brain injuryR01AG077576 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUTLER, TRACY A., LI, YI · 2023 to 2025
$4.6M
PET Measures of CSF Clearance in Preclinical Alzheimer's DiseaseRF1AG057570 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE LEON, MONY J. · 2017 to 2017
$4.1M
CSF Clearance in Sporadic Alzheimer's DiseaseR01AG057848 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI LI, YI · 2018 to 2023
$4.0M
CSF Clearance with 11C-Butanol PET Predicts Amyloid DepositionR56AG058913 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE LEON, MONY J., RUSINEK, HENRY · 2018 to 2018
$861k
NIA NIH HHS R01 AG057848NIA NIH HHS R01 AG077576NIA NIH HHS R56 AG058913NIA NIH HHS RF1 AG057570
6 · The paper itself

Abstract

Following a brief review of brain neurofluid pathways and the general PET technique, we introduce PET imaging of cerebrospinal fluid and interstitial fluid dynamics. Our summary includes both our published and unpublished observations on the modeling of PET imaging for neurofluid quantification in aging, Alzheimer's disease, and in the presence of amyloid lesions. We identify the limitations of PET imaging and point to validations and potential future directions.

Indexed as

BrainNeuroimagingPositron-Emission TomographyAlzheimer DiseaseHumans(11)C-Butanol PETAlzheimer’s diseaseCerebrospinal fluid (CSF)CSF clearanceGlymphatic functionInterstitial fluid (ISF)Kinetic modelingPositron emission tomography

Identifiers

PMID40210379
PMCPMC13234954

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.