Observational studyOpen heart2025
Prevalence of ventricular parasystole in patients with cardiac sarcoidosis: correlation between parasystole and inflammation in ventricular fibrillation.
Observational study in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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18 authors.
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Abstract
backgroundVentricular parasystole is strongly associated with ventricular fibrillation (VF) in patients with non-ischaemic cardiomyopathy. However, the relationship between ventricular parasystole and cardiac sarcoidosis (CS) remains unclear. The purpose of this study was to examine the prevalence of parasystole in patients with CS.
methodsThis was a retrospective observational study of 214 consecutive patients diagnosed with CS (mean age: 69±12 years, 104 males, median follow-up period: 6.8 years (IQR: 3.2-10.7) in our centre. We investigated parasystole in the patients who developed ventricular arrhythmia (VA) using 9886 ECGs, 280 Holter ECGs and 6391 implantable cardioverter defibrillator interrogation records. Classic parasystole was defined as three ventricular ectopic beats with the same morphology, occurring at integer-multiple intervals but with different coupling intervals (CI) on ECG. New parasystole was defined as two ventricular ectopic beats with a CI difference of more than 120 ms. We also analysed the correlation between inflammation sites and parasystole morphology observed on a 12-lead ECG.
resultsVA was identified in 95 patients (33.7%), and 22 developed VF (23.2%). Parasystole was observed in 12 of the 22 patients with VF (classic: 5, new: 7), 20 of 73 with ventricular tachycardia (classic: 5, new: 15) and 44 of 118 without VA (classic: 16, new: 28). Parasystole was significantly more common in the VF group than in the non-VF group (p=0.049). The site of inflammation observed on
conclusionVentricular parasystole was detected in one-third of patients with CS in this study, especially those with VF. The presence of parasystole and inflammation may predict the occurrence of VF in patients with CS.
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