Evidence map›Paper›PMID 40210201›Full record

ArticleACS applied materials & interfaces2025

Passive Transport across Cell Membranes beyond the Overton Rule: Insights from Solute Exchange in Vesicles and Molecular Dynamics of Atropisomers.

Margarida M Cordeiro, Alexandre C Oliveira, Paulo E Abreu, Luis G Arnaut, Maria João Moreno, Luís M S Loura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Margarida M CordeiroCoimbra Chemistry Center, Institute of Molecular Sciences (CQC-IMS), University of Coimbra, 3004-535 Coimbra, Portugal.
Alexandre C OliveiraCoimbra Chemistry Center, Institute of Molecular Sciences (CQC-IMS), University of Coimbra, 3004-535 Coimbra, Portugal.ORCID 0000-0001-7920-7773
Paulo E AbreuCoimbra Chemistry Center, Institute of Molecular Sciences (CQC-IMS), University of Coimbra, 3004-535 Coimbra, Portugal.ORCID 0000-0003-2393-0203
Luis G ArnautCoimbra Chemistry Center, Institute of Molecular Sciences (CQC-IMS), University of Coimbra, 3004-535 Coimbra, Portugal.ORCID 0000-0002-3223-4819
Maria João MorenoCoimbra Chemistry Center, Institute of Molecular Sciences (CQC-IMS), University of Coimbra, 3004-535 Coimbra, Portugal.ORCID 0000-0003-3076-9905
Luís M S LouraCoimbra Chemistry Center, Institute of Molecular Sciences (CQC-IMS), University of Coimbra, 3004-535 Coimbra, Portugal.ORCID 0000-0002-1051-2312

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioavailability of a drug is critically dependent on its cell membrane permeability. Empirical rules guiding drug design consolidated the dogma that large molecules cannot cross cell membranes by passive diffusion. However, the more amphiphilic atropisomers of redaporfin, an 1135 Da bacteriochlorin photosensitizer used in photodynamic therapy, exhibited fast cell uptake and high photodynamic activity

Indexed as

Cell MembraneLipid BilayersMolecular Dynamics SimulationPhotosensitizing AgentsPorphyrinsBiological TransportLipid BilayersPhotosensitizing AgentsPorphyrins3D molecular descriptorsdrug bioavailabilitymembrane permeabilitypartition diffusion

Identifiers

PMID40210201
PMCPMC12022943

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.