Evidence map›Paper›PMID 40210192›Full record

ArticleExperimental eye research2025

Intraretinal variation in disease severity in the Oat

Robin J Wilder, Andrea F An, Brent A Bell, Georgia Fossett, Alaina M Wojciechowski, Ivan Shpylchak, Katherine E Uyhazi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Robin J WilderF.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Andrea F AnF.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Brent A BellF.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Georgia FossettF.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Alaina M WojciechowskiF.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Ivan ShpylchakF.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Katherine E UyhaziF.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address: katherine.uyhazi@pennmedicine.upenn.edu.

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
RESEARCH ON NORMAL AND ABNORMAL MECHANISMS OF VISIONST32EY007035 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Diego Contreras, Jessica I.W. Morgan · 1985 to 2026
$4.9M
Spectralis Tracking HRA-Optical Coherence Tomography 2 (OCT2): Advanced Ophthalmic Imaging for Small and Large Animal StudiesS10OD026860 · OD · UNIVERSITY OF PENNSYLVANIA · PI BENNETT, JEAN · 2019 to 2019
$239k
NEI NIH HHS P30 EY001583NEI NIH HHS T32 EY007035NIH HHS S10 OD026860
6 · The paper itself

Abstract

Gyrate atrophy is an autosomal recessive retinal degeneration caused by pathogenic variants in the gene encoding ornithine aminotransferase (OAT), a mitochondrial enzyme required for ornithine degradation. Deficiency of OAT leads to hyperornithinemia and progressive chorioretinal atrophy that results in permanent vision loss. Strict dietary arginine restriction can slow the progression of the disease, but long-term adherence to the diet is challenging and not curative. Here, we characterize the retinal structure and function of the retarded hair growth (Oat

Indexed as

Gyrate AtrophyRetinaRetinal Pigment EpitheliumAnimalsDisease Models, AnimalElectroretinographyMiceMice, Inbred C57BLOrnithine-Oxo-Acid TransaminaseSeverity of Illness IndexTomography, Optical CoherenceOrnithine-Oxo-Acid TransaminaseGyrate atrophyOATOrnithine aminotransferaseRetinaRetinal pigment epithelium

Identifiers

PMID40210192
PMCPMC13101453

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.