ArticleBiological psychiatry2025
Hyperpolarization-Activated Channel 1 Modulates Resilience and Susceptibility to Social Avoidance Induced by Witnessing Social Defeat Stress.
Article in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Pyramidal-cell-specific hemispheric asymmetry shapes dorsoventral CA1 dynamics during rest and exploratory behavior.bioRxiv : the preprint server for biology · 2026Article
- Effects of post-stress corticosterone on hippocampal excitability and behavior involving hyperpolarization-activated cation channel 1 function.Translational psychiatry · 2026Article
- Not just a witness: Highlighting the utility of witness social defeat stress for the examination of neuroimmune-cardiovascular interactions across diverse populations.Neurobiology of stress · 2025Review
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4 authors.
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Abstract
backgroundPhysical social defeat stress models are widely used to study chronic stress. In contrast, witnessing social defeat, observing aggression without direct involvement, is less studied but has growing relevance to disorders such as posttraumatic stress disorder (PTSD). The role of hyperpolarization-activated channel 1 (HCN1) in stress responses to witnessing social defeat is unclear, and the effects of prolonged exposure (PE) therapy, commonly used in PTSD treatment, have not been tested in this context.
methodsMale mice were subjected to either chronic physical stress or witnessing social defeat stress. Behavioral assessments included measures of social avoidance, stress reactivity, fear memory, and spatial working memory. Neuronal excitability, h current (I
resultsMice that witnessed social defeat exhibited behavioral impairments similar to physically defeated mice, showing changes in social behavior, fear memory, spatial working memory, and stress responses. These impairments were linked to increased HCN1 expression, elevated I
conclusionsHCN1 channels play a key role in regulating stress responses and contribute to resilience or susceptibility following social defeat.
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