ArticleGastrointestinal endoscopy2025
A combined endoscopy and functional lumen imaging probe panometry approach can expedite diagnosis of esophageal motility disorders.
Article in Gastrointestinal endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Performance and Reproducibility of the CARS Endoscopic Score in Achalasia: A Systematic Review and Meta-Analysis.Neurogastroenterology and motility · 2026Pooled it
- Functional Lumen Imaging Probe (EndoFLIP) in Upper Gastrointestinal Disorders: Current Evidence, Clinical Applications, and Future Perspectives.Diseases (Basel, Switzerland) · 2026Review
- Accuracy of Novice Raters for Esophageal Motility Classifications Using Functional Lumen Imaging Probe Panometry.Neurogastroenterology and motility · 2026Article
- Gastrointestinal endoscopy for physiological assessment in functional gastrointestinal disorders: a perspective.Frontiers in medicine · 2026Article
- Validation of Functional Lumen Imaging Probe Panometry Esophageal Motility Classification Version 2.0: A Study of 805 Patients.Neurogastroenterology and motility · 2025Article
- Diagnosis and Management of Gastroesophageal Reflux Disease: Current Insights.Clinical and experimental gastroenterology · 2025Review
- [[Redefining the Initial Endoscopy Evaluation of Esophageal Symptoms: Toward a PrecisionBased Diagnostic Paradigm]].Acta gastroenterologica LatinoamericanaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
BACKGROUND AND
aimsUpper endoscopy and functional lumen imaging probe (FLIP) panometry offer a complementary approach to diagnose esophageal motility disorders during the sedated endoscopy encounter. This study aimed to evaluate an approach combining an endoscopic motility score and FLIP panometry to diagnosis esophageal motility disorders.
methodsAdult patients who completed upper endoscopy with FLIP and high-resolution manometry (HRM) were included. Endoscopic videos were reviewed to determine the Contents, Anatomy, Resistance, Stasis (CARS) score. Esophagogastric junction (EGJ) opening and contractility profile were applied to derive a FLIP panometry motility classification. HRM and Chicago Classification version 4.0 (CCv4.0) were used as the reference standard.
resultsA total of 224 patients (mean age, 52 ± 18 years; 51% female) were included; 112 (50%) had achalasia or conclusive EGJ outflow obstruction (EGJOO) according to HRM and CCv4.0. None of 63 patients with CARS score 0 to 1 and normal EGJ opening on FLIP panometry had achalasia/conclusive EGJOO (100% negative predictive value); 65 of 65 patients with CARS score ≥4 and FLIP panometry classifications of nonspastic obstruction (n = 65) had achalasia or conclusive EGJOO, which was nonspastic in 63 (97% positive predictive value). Of the 96 of 224 (43%) patients with other CARS/FLIP combinations, 47 (49%) had achalasia or conclusive EGJOO.
conclusionsAn approach using endoscopy (CARS score) and FLIP panometry (endoscopy with FLIP panometry [mechanics, anatomy, physiology]) identified actionable esophageal motility disorders at the point-of-care endoscopy encounter. While additional validation is planned, this approach offers a well tolerated method that addresses limitations of HRM. Applied to the index endoscopic encounter, this approach could expedite management, reducing need for HRM in some patients versus triaging toward additional testing in others.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.