Evidence map›Paper›PMID 40209957›Full record

ArticleThe Journal of biological chemistry2025

GLUT2/SLC2A2 is a bi-directional urate transporter.

Yu Toyoda, Ryuichiro Shigesawa, Tony R Merriman, Hirotaka Matsuo, Tappei Takada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yu ToyodaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan; Department of Pharmacy, The University of Tokyo Hospital, Bunkyo, Tokyo, Japan.
Ryuichiro ShigesawaDepartment of Pharmacy, The University of Tokyo Hospital, Bunkyo, Tokyo, Japan.
Tony R MerrimanDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Hirotaka MatsuoDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan. Electronic address: matsuo29@gmail.com.
Tappei TakadaDepartment of Pharmacy, The University of Tokyo Hospital, Bunkyo, Tokyo, Japan. Electronic address: tappei-tky@g.ecc.u-tokyo.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent genetic studies showed an association between solute carrier 2A2 (SLC2A2), which encodes glucose transporter 2 (GLUT2), and serum urate concentrations; however, urate transport activity of GLUT2 has not been studied contrary to its function as a sugar transporter. Here, we hypothesized that GLUT2 acts also as a urate transporter, which led us to conduct cell-based functional analyses using HEK-derived 293A cells. We found that radiolabeled [8-

Indexed as

Glucose Transporter Type 2Organic Anion TransportersUric AcidBiological TransportGlucoseHEK293 CellsHumansGlucoseGlucose Transporter Type 2Organic Anion TransportersSLC2A2 protein, humanurate transporterUric AcidGWASurate exporterurate handlingurate importeruric acid

Identifiers

PMID40209957
PMCPMC12143617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.