Evidence map›Paper›PMID 40209933›Full record

SynthesisOphthalmology. Retina2025

Phenotypic Spectrum of Benign Lobular Inner Nuclear Layer Proliferations: A Multicenter Analysis and Review of the Literature.

Michael Javaheri, Christian J Sanfilippo, Sundeep K Kasi, Rachel Chen, Jose M Ruiz-Moreno, Carol L Shields, David A Saperstein, Amy Yuan, Brandon J Lujan, Heinrich Heimann and 5 more

Erratum issuedAbstract readMulticenter StudySystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Ophthalmology. Retina, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Michael JavaheriDepartment of Ophthalmology, Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California; Retina Specialists of Beverly Hills, Beverly Hills, California.
Christian J SanfilippoThe Retina Partners, Los Angeles, California.
Sundeep K KasiThe Retina Group of Washington, Alexandria, Virginia.
Rachel ChenThe Retina Group of Washington, Alexandria, Virginia.
Jose M Ruiz-MorenoHospital Universitario Puerta de Hierro-Majadahonda. Madrid, Spain.
Carol L ShieldsOcular Oncology Service, Wills Eye Hospital, Philadelphia, Pennsylvania.
David A SapersteinPacific Northwest Retina, Seattle, Washington.
Amy YuanPacific Northwest Retina, Seattle, Washington.
Brandon J LujanCasey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Heinrich HeimannOcular Oncology Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom.
Rutika DodejaAlder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom.
Chris BergstromRetina Consultants of Carolina, Greenville, South Carolina.
Özge YanıkDepartment of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.
Jesse L BerryDepartment of Ophthalmology, Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California; Department of Surgery, The Vision Center, Children's Hospital Los Angeles, Los Angeles, California.
Aaron NagielDepartment of Ophthalmology, Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California; Department of Surgery, The Vision Center, Children's Hospital Los Angeles, Los Angeles, California. Electronic address: anagiel@chla.usc.edu.

Funding

Development and Maintenance of the Human Photoreceptor-Bipolar Cell Synapse.K08EY030924 · NEI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI NAGIEL, AARON · 2020 to 2024
$1.1M
NEI NIH HHS K08 EY030924
6 · The paper itself

Abstract

objectiveTo report the clinical and imaging features of 8 new and 9 published cases with benign lobular inner nuclear layer proliferations (BLIPs).

designRetrospective case series and literature review.

participantsEight previously unreported patients from 7 institutions internationally and 10 reported cases in the literature.

methodsRetrospective analysis of clinical and imaging features of BLIPs including systematic review of published cases using relevant terms. MAIN OUTCOMES AND MEASURES: Description of multimodal imaging and systemic findings in 17 patients with BLIPs.

resultsEight new cases and 10 previously published cases with BLIPs were reviewed for clinical features, systemic associations, and imaging findings. The tumors were mostly unilateral (16 of 18 cases; 88%), associated with ipsilateral grouped congenital hypertrophy of the retinal pigment epithelium lesions (16 of 20 eyes; 80%), and located posterior to the equator. In all eyes, the tumors were multifocal, and many had curvilinear extensions that extended beyond the central tumor lobules. OCT demonstrated these lesions to be centered within the inner nuclear layer at the border of the inner plexiform layer with no invasion of adjacent layers. Visual acuity was normal (mean: 0.024 logarithm of the minimum angle of resolution; range: -0.01 to 0.3) in all cases, and most patients were asymptomatic. No plausible genetic or systemic associations could be identified.

conclusionsThis expanded series of BLIPs further refines the clinical characteristics and imaging findings associated with this newly described benign retinal tumor. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Fluorescein AngiographyRetinal Pigment EpitheliumTomography, Optical CoherenceVisual AcuityAdultAgedFemaleFundus OculiHumansMaleMiddle AgedPhenotypeRetrospective StudiesHamartomaInner nuclear layerRetinal lesionRetinal tumorRetinoblastoma

Identifiers

PMID40209933
PMCPMC12353968

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.