Evidence map›Paper›PMID 40209646›Full record

ArticleBiosensors & bioelectronics2025

Bilisense: An affordable sensor for on-site diagnosis of jaundice and prevention of kernicterus.

Victor Ong, Mona A Mohamed, Haozheng Ma, Abdulrahman Al-Shami, Sina Khazaee Nejad, Farbod Amirghasemi, Asna Tabassum, Michael Jayden Lee, Alexander Rohleder, Cathy Zhu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Victor OngAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Mona A MohamedAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Haozheng MaAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Abdulrahman Al-ShamiAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Sina Khazaee NejadAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Farbod AmirghasemiAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Asna TabassumAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Michael Jayden LeeAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Alexander RohlederAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Cathy ZhuAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Chur TamAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Patrick NowlenAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA.
Maral P S MousaviAlfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, STE 140, Los Angeles, 90089, CA, USA; Department of Chemistry, University of Southern California, 3620 McClintock Ave, Los Angeles 90089, CA, USA; Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles 90033, CA, USA; Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Avenue, Los Angeles 90089, CA, USA. Electronic address: mousavi.maral@usc.edu.

Funding

Building a two-way communication system: Bio-orthogonal superhydrophobic nanoparticles for controlled stimulation and real-time sensing of neurotransmittersDP2GM150018 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MOUSAVI, MARAL · 2022 to 2025
$2.3M
NIGMS NIH HHS DP2 GM150018
6 · The paper itself

Abstract

Bilirubin (BR) in blood serum is elevated during jaundice (a common complication among newborns). Accessible and frequent monitoring of BR is necessary for timely diagnosis and intervention. This work developed a low-cost electrochemical sensor for point-of-care and at-home measurement of BR. The sensor measures BR based on its oxidation at a laser-induced graphene electrode. A microfluidic channel for sample wicking is embedded on the electrodes to bifurcate the blood sample into two zones to allow measurement of different BR forms (conjugated and unconjugated). One zone remains bare, while the second zone is impregnated with caffeine sodium benzoate, which acts as an accelerant to release albumin-bound BR and makes it accessible for electrochemical oxidation. The sensors demonstrate linear response in the concentration range of 100 to 500 µmolL

Indexed as

BilirubinBiosensing TechniquesJaundiceKernicterusElectrochemical TechniquesEquipment DesignGraphiteHumansInfant, NewbornPoint-of-Care SystemsBilirubinGraphiteBilirubin speciationElectrochemical sensingInfant healthJaundiceLaser-induced graphene (LIG)Point-of-care sensing

Identifiers

PMID40209646
PMCPMC12721466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.