ArticleRedox biology2025
Oxidative damage to lung mitochondrial DNA is a key contributor to the development of chemical lung injury.
Abstract read
In one paragraph
Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Mitochondria-Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA-Driven Inflammation at the Source.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Combined trauma and toxic inhalation in war and disaster medicine: alveolar-capillary barrier failure and respiratory countermeasures.Critical care (London, England) · 2026Review
- Mitochondrial-endoplasmic reticulum interactions in lung diseases.Cell death & disease · 2026Review
- Cardiotoxin from Naja atra Activates the NLRP3/Caspase-1/GSDMD Pyroptosis Pathway to Induce Skin Tissue Injury.PLoS neglected tropical diseases · 2026Article
- A DPEP1-Binding and mitochondria-targeted nanocomposite relieves acute respiratory distress syndrome by inhibiting Drp1-mediated mitochondria fission.Materials today. Bio · 2026Article
- Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions.Cell proliferation · 2026Review
- Moderate NEFA reprogram early follicular development and oocyte competence: evidence for a targetable redox mechanism.Frontiers in nutrition · 2026Article
- Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities.Frontiers in immunology · 2026Review
- Celastrol-Based Hybrid Prodrug Ameliorates ALI by Spatiotemporally Consecutive Dual-Targeting GLUT1/Drp1 to Reestablish Mitochondrial Homeostasis.International journal of biological sciences · 2026Article
- Chlorine-induced severe ARDS in an adolescent rescued with VV-ECMO: a case report with 6-month functional follow-up.Frontiers in pediatrics · 2026Article
- Airborne chloride exposure and benign prostatic hyperplasia risk.BMC research notes · 2025Article
- Chlorine gas poisoning by trichloroisocyanuric acid and respiratory failure: a case report of a 49-year-old patient.Frontiers in medicine · 2025Article
- Signaling pathways of marine-derived natural products on lung injury: from theFrontiers in pharmacology · 2025Review
Corrections and comments
- Update of
Authors and funding
16 authors.
Shubham DubeyDepartment of Anesthesiology and Perioperative Medicine, USA.
Zhihong YuDepartment of Anesthesiology and Perioperative Medicine, USA.
Emily Morgan StephensDepartment of Anesthesiology and Perioperative Medicine, USA.
Ahmed LazrakDepartment of Anesthesiology and Perioperative Medicine, USA.
Israr AhmadDepartment of Anesthesiology and Perioperative Medicine, USA.
Saurabh AggarwalDepartment of Anesthesiology and Perioperative Medicine, USA.
Shaida AndrabiDepartment of Pharmacology and Toxicology, USA.
M Iqbal HossainDepartment of Pharmacology and Toxicology, USA.
Tamas JillingDepartment of Pediatrics, Division of Neonatology, USA.
Solana R FernandezDepartment of Radiology, The Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jennifer L BartelsDepartment of Radiology, The Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Suzanne E LapiDepartment of Radiology, The Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
James A MobleyDepartment of Anesthesiology and Perioperative Medicine, USA.
Viktor M PastukhDepartment of Pharmacology and Center for Lung Biology, University of South Alabama College of Medicine, Mobile, AL, 36688, USA.
Mark N GillespieDepartment of Pharmacology and Center for Lung Biology, University of South Alabama College of Medicine, Mobile, AL, 36688, USA.
Sadis MatalonDepartment of Anesthesiology and Perioperative Medicine, USA. Electronic address: smatalon@uabmc.edu.
Funding
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9MPATHOPHYSIOLOGY OF SUBLETHAL OXYGEN IN INJURED LUNGSR01HL031197 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARK N GILLESPIE, Sadis Matalon · 1985 to 2026
$4.2MChronic Widespread Pain in HIV: Novel Mechanisms and TherapeuticsR01DA049657 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGGARWAL, SAURABH · 2021 to 2025
$1.8MIdentification of AMD3100 (Plerixafor) as a potential lead compound for chlorine toxicityU01ES033265 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGGARWAL, SAURABH · 2021 to 2023
$1.3MNCI NIH HHS P30 CA013148NHLBI NIH HHS R01 HL031197NIDA NIH HHS R01 DA049657NIEHS NIH HHS U01 ES033265
Abstract
Humans exposed to chlorine (Cl
Indexed as
DNA DamageDNA, MitochondrialLungLung InjuryOxidative StressAnimalsDisease Models, AnimalDNA GlycosylasesHumansMaleMiceMice, Inbred C57BLMitochondriaOxidation-ReductionDNA GlycosylasesDNA, MitochondrialOgg1 protein, mouse8-Oxoguanine DNA glycosylase (OGG1)Acute lung injuryBioenergeticsChlorineProteomicsSystems biology
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Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.