ArticlePloS one2025
Comparative transcriptome analysis of Labeo calbasu (Hamilton, 1822) from polluted and non-polluted rivers in India.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Labeo calbasu (L. calbasu) is an important detrivore fish in an ecosystem. So, the present transcriptome study was undertaken in relation to polluted and non-polluted water sources from a natural perennial river system. The Illumina NovaSeq 6000 platform was used to perform transcriptome analysis on liver samples of L. calbasu that were collected from the Ganga and Yamuna rivers. From 8744 differentially expressed genes (DEGs), 2538 were upregulated, and 6206 were downregulated in response to pollution stress. Biologic process (BP), cellular component (CC), molecular function (MF), and Gene Ontology (GO) demonstrated that relevant genes were associated with peptide metabolic process, cytosol, RNA binding, etc. In the Kyoto Encyclopedia of Genes and Genome (KEGG) analysis, ribosomal and metabolic pathways were more important due to the high False discovery rate (FDR) and the involvement of many genes. Transcripts of uncertain coding potential (TUCP) and various RNAs like mRNAs and long noncoding RNAs (lncRNAs) orchestrate fish cellular responses to environmental stressors in polluted waters, where aquatic ecosystems are threatened. FGG mRNA is co-expressed in both up and down-regulation in the liver of L. calbasu. In conclusion, L. calbasu collected from the Yamuna River have highly pollution-induced ribosomal pathways involving genes like Rpl19, rpl23Ae, rps2e, rps10e, rps15e, and rps7e, etc, which is important for pollution biomarker study. RANBP2 and egr1 lncRNA are the most significantly interlinked with ndc1 and fosab lncRNA.
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