ArticleAccounts of chemical research2025
Advancing Total Synthesis Through Skeletal Editing.
Article in Accounts of chemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Oxetane-to-azetidine skeletal editing.Nature chemistry · 2026Article
- Violet-light-induced ring expansion of 2-aryl-1,3-indandiones with chlorodiazirines toward 1,4-naphthoquinones.Chemical science · 2026Article
- Skeletal Reorganization of Cycloalkylamines Into Angular Azatetracyclic Scaffolds.Angewandte Chemie (International ed. in English) · 2026Article
- Single-carbon insertion enables conversion of cyclopropenes into cyclobutenes: access to oxaspiro[2.3]hexenes.Chemical science · 2026Article
- Transforming Molecular Synthesis With Large Language Models.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Divergent and precise alkaloid remodelling with a small suite of reactions.Nature chemistry · 2026Article
- Total synthesis of pyridine-containing natural product Lycodine as well as its dimers and derivatives.Molecular diversity · 2026Review
- N-O Dual Functional Group Transposition via Energy Transfer Photocatalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reprogramming RiPP scaffolds through skeletal editing unlocks chemical space.Chemical science · 2026Article
- Unified Access to Biaryl-Bridged Linkages Unlocks Structural Diversification of Noncanonical Cyclic Peptides.Journal of the American Chemical Society · 2026Article
- Photoinduced H-Bonding EDA complex-enabled skeletal editing of furans to pyridazines.Nature communications · 2026Article
- Skeletal Editing via Diastereoselective Ring Expansion Enables Enantioenriched Tetrasubstituted ΔJACS Au · 2026Article
- Unified Total Synthesis ofJournal of the American Chemical Society · 2025Article
- Synthesis of Thiophenes from Pyridines Using Elemental Sulfur.Angewandte Chemie (International ed. in English) · 2025Article
- Comparative analysis of complanadine A total syntheses.Beilstein journal of organic chemistry · 2025Review
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2 authors.
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Abstract
Total synthesis has long been a proving ground for advancing chemical thought, pushing chemists to develop strategies that not only replicate nature's complexity but often surpass it. The pursuit of efficiency, practicality, and elegance continues to challenge and reshape the guiding principles of total synthesis. In recent years, skeletal editing has emerged as a powerful strategy for reconfiguring skeletal frameworks in ways that were previously difficult to imagine. Unlike conventional chemical synthesis approaches, which primarily rely on the logic of bond construction reactions and functional group manipulations, skeletal editing introduces elements that allow for atom insertion, deletion, and exchange and skeletal rearrangement/reorganization by harnessing the potential energy and reactivity of certain structural motifs and morphing them into new electronic and spatial configurations. The logic of modern skeletal editing has been fueling the development of new editing methods and advancing the fields of total synthesis, medicinal chemistry, materials science, and others.In this Account, we detail our program using skeletal editing-based retrosynthetic logic to facilitate natural product synthesis. We first highlight two one-carbon insertion editing strategies utilizing the Ciamician-Dennstedt rearrangement and the Büchner-Curtius-Schlotterbeck ring expansion to streamline the total syntheses of complanadine and phleghenrine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.