Evidence map›Paper›PMID 40209042›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Photocontrolled Release of Urea Enables the Detection of Urea-Urease Intermediates by Cryo-FTIR.

Caterina G C Marques Netto, Sarah Bell, Caio B Castro, Pedro Henrique Machado, Vatsal Purohit, Katherine M Davis, Ana Paula L Batista, R Brian Dyer

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caterina G C Marques NettoDepartamento de Quimica, Universidade Federal de São Carlos, Rod. Washington Luiz, Km 235, s/n, São Carlos, SP, 13565-905, Brazil.ORCID 0000-0002-3285-4129
Sarah BellDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA, 30030, USA.
Caio B CastroDepartamento de Quimica, Universidade Federal de São Carlos, Rod. Washington Luiz, Km 235, s/n, São Carlos, SP, 13565-905, Brazil.
Pedro Henrique MachadoDepartamento de Quimica, Universidade Federal de São Carlos, Rod. Washington Luiz, Km 235, s/n, São Carlos, SP, 13565-905, Brazil.
Vatsal PurohitDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA, 30030, USA.
Katherine M DavisDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA, 30030, USA.
Ana Paula L BatistaDepartamento de Quimica, Universidade Federal de São Carlos, Rod. Washington Luiz, Km 235, s/n, São Carlos, SP, 13565-905, Brazil.
R Brian DyerDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA, 30030, USA.

Funding

Beckman Young Investigator ProgramCAPES 001FAPESP 2019/25762-7
6 · The paper itself

Abstract

Caged compounds are a valuable tool to photocontrol the release of enzymatic substrates in a reaction. For example, caged urea molecules were proposed to control urea delivery to urease reactions and aid the determination of the catalytic mechanism of this enzyme. Owing to the success of several caged compounds based on ruthenium complexes, we synthesized a new inorganic caged urea (RuBpy-urea) and monitored the release of free urea by infrared spectroscopy upon irradiation. Transient infrared absorption (TRIR) indicates diffusion-controlled release of urea, and kinetics studies after photolysis demonstrate the functionality of the new caged molecule for photocontrolled delivery of urea to urease. Coupling photocontrolled delivery of urea to cryo-FTIR (fourier transform infrared spectroscopy) revealed that inhibition of urease results in different FTIR spectrum than the one observed for the noninhibited urease.

Indexed as

UreaUreaseKineticsRutheniumSpectroscopy, Fourier Transform InfraredRutheniumUreaUreaseCaged ureaCryo‐FTIRPhotocontrolled deliveryReaction intermediatedUrease

Identifiers

PMID40209042
PMCPMC12402847

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.