Evidence map›Paper›PMID 40208942›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Astrocytic Ryk signaling coordinates scarring and wound healing after spinal cord injury.

Zhe Shen, Bo Feng, Wei Ling Lim, Timothy Woo, Yanlin Liu, Silvia Vicenzi, Jingyi Wang, Brian K Kwon, Yimin Zou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Zhe ShenDepartment of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-7740-6725
Bo FengDepartment of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0001-8494-5359
Wei Ling LimDepartment of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.
Timothy WooDepartment of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.
Yanlin LiuDepartment of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.
Silvia VicenziDepartment of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0001-5670-7169
Jingyi WangDepartment of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.
Brian K KwonDepartment of Orthopaedics, International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Yimin ZouDepartment of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-1092-5547

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Characterizing Wnt Signaling Pathways in Axon GuidanceR37NS047484 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZOU, YIMIN · 2019 to 2025
$5.2M
Develop a combinatorial therapy for spinal cord injuryR01NS105961 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI LI, SHUXIN, ZOU, YIMIN · 2018 to 2022
$1.7M
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RO1 NS105961NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS105961NINDS NIH HHS R37 NS047484
6 · The paper itself

Abstract

Wound healing after spinal cord injury involves highly coordinated interactions among multiple cell types, which are poorly understood. Astrocytes play a central role in creating a border against the non-neural lesion core. To do so, astrocytes undergo dramatic morphological changes by first thickening and elongating their processes and then overlapping them to form a physical barrier. We show here that the expression of a cell-surface receptor, Ryk, is induced in astrocytes after injury in both rodent and human spinal cords. Astrocyte-specific knockout of

Indexed as

AstrocytesCicatrixSignal TransductionSpinal Cord InjuriesWound HealingAnimalsHumansMiceMice, KnockoutRatsastrocytesglial scarmicrogliaRykspinal cord injury

Identifiers

PMID40208942
PMCPMC12012454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.