Evidence map›Paper›PMID 40208941›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization.

Xueqi Zhao, Yue Zhao, Zhu Li, Huan Liu, Wenhao Fu, Feng Chen, Ying Sun, Daqian Song, Chunhai Fan, Yongxi Zhao

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xueqi ZhaoJilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, College of Chemistry, Jilin University, Changchun 130012, Jilin, People's Republic of China.ORCID 0009-0006-5769-7955
Yue ZhaoInstitute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, People's Republic of China.ORCID 0009-0000-2942-5836
Zhu LiInstitute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, People's Republic of China.ORCID 0009-0007-2161-529X
Huan LiuInstitute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, People's Republic of China.ORCID 0000-0002-9083-2251
Wenhao FuInstitute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, People's Republic of China.ORCID 0009-0009-6891-8452
Feng ChenInstitute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, People's Republic of China.
Ying SunJilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, College of Chemistry, Jilin University, Changchun 130012, Jilin, People's Republic of China.ORCID 0000-0002-6820-3184
Daqian SongJilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, College of Chemistry, Jilin University, Changchun 130012, Jilin, People's Republic of China.ORCID 0009-0002-1476-6966
Chunhai FanNew Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhangjiang Institute for Advanced Study and National Center for Translational Medicine, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.ORCID 0000-0002-7171-7338
Yongxi ZhaoInstitute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, People's Republic of China.ORCID 0000-0002-1796-7651

Funding

Innovation Capability Support Program of Shaanxi 2023-CX-TD-62MOST | National Key Research and Development Program of China (NKPs) 2023YFB3210103MOST | National Natural Science Foundation of China (NSFC) 22004096MOST | National Natural Science Foundation of China (NSFC) 22125404MOST | National Natural Science Foundation of China (NSFC) 22474107Natural Science Foundation of Shaanxi Province (Shaanxi Natural Science Foundation) 2023JC-JQ-23
6 · The paper itself

Abstract

Cellular structure maintenance and function regulation critically depend on the composition and spatial distribution of numerous membrane proteins. However, current methods face limitations in spatial coverage and data scalability, hindering the comprehensive analysis of protein interactions in complex cellular nanoenvironment. Herein, we introduce

Indexed as

High-Throughput Nucleotide SequencingMembrane ProteinsSequence Analysis, DNABreast NeoplasmsCell Line, TumorDNA ProbesDNA, Single-StrandedEpithelial Cell Adhesion MoleculeErb-b2 Receptor Tyrosine KinasesFemaleHumansDNA ProbesDNA, Single-StrandedEPCAM protein, humanEpithelial Cell Adhesion MoleculeERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesMembrane ProteinsDNA encodinghigh-throughput sequencingmembrane proteinsnucleic acid amplificationproximity detection

Identifiers

PMID40208941
PMCPMC12012555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.