ArticleTranslational vision science & technology2025
Causal Relationship Between Common Allergic Diseases and Keratoconus: A Two-Sample Mendelian Randomization Study.
Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Sex Hormone Imbalance in Keratoconus: Estrogen-Mediated Collagen Remodeling and Biomechanical Weakening.Investigative ophthalmology & visual science · 2026Article
- Mendelian randomization studies in atopic dermatitis: causal insights across omics layers.Frontiers in immunology · 2026Review
- Asthma and Keratoconus: A Vision at Risk and the Urgency of Early Screening.Pakistan journal of medical sciences · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the impact of several allergic diseases on the development of keratoconus (KC) from a genetic perspective. Methods: Data from multiple genome-wide association studies involving European ancestry individuals were used. Ultimately, 613 allergic conjunctivitis (AC) cases and 474,657 controls, 4387 allergic rhinitis (AR) cases and 471,273 controls, 4859 allergic asthma cases and 135,449 controls, 1169 allergic urticaria cases and 212,464 controls, 22,474 atopic dermatitis cases and 774,187 controls, and 311 KC cases and 209,287 controls were included. Then inverse-variance weighted (IVW) method, potential pleiotropy, heterogeneity, and leave-one-out analyses were assessed to investigate the causal effects of those allergic diseases on KC. Results: IVW estimates indicated that allergic asthma promoted the development of KC (IVW odds ratio [OR] = 2.18; 95% confidence interval [CI], 1.007-4.707; P = 0.048). However, the IVW estimates show that AC (IVW OR = 1.02; 95% CI, 0.960-1.086; P = 0.513), AR (OR = 0.26; 95% CI, 0.037-1.754; P = 0.165), atopic dermatitis (IVW OR = 1.50; 95% CI, 0.942-2.395; P = 0.088), allergic urticaria (IVW OR = 1.11; 95% CI, 0.822-1.511; P = 0.485) are not significantly causally associated with KC. Conclusions: Allergic asthma may promote KC by increasing allergy-related ocular inflammation. Translational Relevance: The possibility of increased KC in patients with allergic asthma should be considered.
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Registered trials
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