A Method to Evaluate Skin and Skin Substitute Mechanical Properties Using a Suction Device.

Vivienne Woodtli, David Sachs, Alberto Stracuzzi, Serjosha Robmann, Thomas Biedermann, Sophie Böttcher-Haberzeth, Bettina Thumm

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Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Vivienne WoodtliPediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.

David SachsCitus AG, c/o EMPA, Dübendorf, Switzerland.

Alberto StracuzziCitus AG, c/o EMPA, Dübendorf, Switzerland.

Serjosha RobmannCitus AG, c/o EMPA, Dübendorf, Switzerland.

Thomas BiedermannChildren's Research Center (CRC), University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.

Sophie Böttcher-HaberzethPediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.

Bettina ThummCitus AG, c/o EMPA, Dübendorf, Switzerland. bettina.thumm@citus-ag.com.

Funding

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6 · The paper itself

Abstract

Optimizing skin tissue engineering necessitates the precise and objective assessment of scar quality. One approach to achieve this evaluation is through the measurement of the skin's or skin substitutes specific mechanical properties, such as elasticity and firmness. This chapter introduces a measurement protocol for clinical assessment of these properties using a suction device, known as the Nimble. The Nimble device quantitatively evaluates the mechanical characteristics of the skin by applying controlled negative pressure to elevate the skin to a predetermined level, thereby allowing for the measurement of skin elasticity and other related parameters. In this chapter, we provide a detailed description of the Nimble's operation, including the step-by-step process for conducting measurements, and offer guidance on the interpretation of the collected data to assess scar quality effectively.

Indexed as

SkinSkin, ArtificialSkin Physiological PhenomenaBiomechanical PhenomenaCicatrixElasticityHumansSuctionTissue EngineeringMechanical skin responseScar qualitySkin elasticitySkin substitute mechanical propertySuction device

Identifiers

PMID40208545

DOI10.1016/j.jmbbm.2015.07.022

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