Evidence map›Paper›PMID 40208544›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Ex Vivo Human Skin Model to Study Immediate and Early Local Responses to External Stimuli.

Ines Foessl, Thomas Birngruber, Petra Kotzbeck, Elisabeth Hofmann

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ines FoesslCOREMED-Centre for Regenerative and Precision Medicine, JOANNEUM RESEARCH Forschungsgesellschaft mbH, Graz, Austria. ines.foessl@joanneum.at.
Thomas BirngruberHEALTH - Institute for Biomedical Research and Technologies, JOANNEUM RESEARCH Forschungsgesellschaft mbH, Graz, Austria.
Petra KotzbeckCOREMED-Centre for Regenerative and Precision Medicine, JOANNEUM RESEARCH Forschungsgesellschaft mbH, Graz, Austria.
Elisabeth HofmannCOREMED-Centre for Regenerative and Precision Medicine, JOANNEUM RESEARCH Forschungsgesellschaft mbH, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Local responses of skin tissue to external stimuli are complex, thus exceeding the capability of in vitro methods but do not need the complexity of a whole organism to be simulated. Therefore, we established a human ex vivo skin model in our lab to study the local effects of various stimuli, such as burns and local topic treatments. In this chapter, we describe the experimental setup of the ex vivo model and additional technology of collecting dermal interstitial fluid. Further, we describe how exosome-like vesicles can be enriched from the dermal interstitial fluid, including their proof via nanoparticle tracking.

Indexed as

SkinExosomesExtracellular FluidHumansModels, BiologicalNanoparticlesDermal interstitial fluidEarly responseEx vivoHuman modelSkin

Identifiers

PMID40208544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.