Evidence map›Paper›PMID 40208531›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Engineering a Pigmented Skin Equivalent That Is Responsive to External Stimuli.

Paola De Los Santos Gomez, Kirsty Goncalves, Victoria Maltman, Lucy Smith, Stefan Przyborski

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Paola De Los Santos Gomez *Department of Biosciences, Durham University, Durham, UK.
Kirsty Goncalves *Department of Biosciences, Durham University, Durham, UK.
Victoria MaltmanDepartment of Biosciences, Durham University, Durham, UK.
Lucy SmithDepartment of Biosciences, Durham University, Durham, UK.
Stefan PrzyborskiDepartment of Biosciences, Durham University, Durham, UK. stefan.przyborski@durham.ac.uk.ORCID https://orcid.org/0000-0001-7613-525X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, dermatological research has more widely adopted the use of human skin equivalents (HSEs) to better recreate skin structure and function in vitro, which can act as a preclinical tool. However, many popular HSEs contain only two main cell types: keratinocytes and fibroblasts to model epidermal and dermal compartments respectively. This lack of supporting cell types can be associated with a wide range of limitations, most notably an inaccurate representation of skin's innate response to exogenous stressors such as UV radiation. We have adapted our novel full-thickness skin platform to incorporate human melanocytes that produce melanin and transfer melanin to neighboring keratinocytes, where it is located apically to the nucleus, forming typical supranuclear protective caps. The use of Alvetex

Indexed as

SkinSkin PigmentationTissue EngineeringCells, CulturedFibroblastsHumansKeratinocytesMelaninsMelanocytesTissue ScaffoldsUltraviolet RaysMelaninsMelaninMelanocytesPigmentationSkin equivalentSkin tissue engineeringSkin toneUltraviolet radiation (UVR)

Identifiers

PMID40208531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.