ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2025
Assessing oral and dental health-related quality of life in head and neck cancer patients at 1, 5, and 10 years: a comparison of the EORTC QLQ43, FACT H&N, and the Orthognathic-QLQ questionnaires.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Perioperative immunotherapy in resectable HNSCC: biological rationale to practical multidisciplinary implementation.Frontiers in oncology · 2026Review
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Abstract
purposeNumerous health-related quality of life (HRQoL) questionnaires are available to assess oral HRQoL in patients undergoing treatment for head and neck (H&N) cancer. These multidimensional instruments should have the capacity to detect meaningful clinical oral function/dental changes at different time points. However, the optimal instrument-or combination of instruments-for assessing oral health and dental needs is not clear. We administered three questionnaires (FACT H&N, EORTC QLQ-H&N43, Orthognathic-QLQ) to assess oral and dental HRQoL in a cohort of H&N cancer patients at 1-, 5- and 10-year post-treatment. A secondary aim was to compare these questionnaires to determine which provides the most useful assessment of oral HRQoL and dental care needs.
methodsProspective, single-center study of patients (n = 82) with H&N cancer grouped according to the follow-up time (1, 5, or 10 years). HRQoL was assessed by telephone with the Functional Assessment of Cancer Therapy (FACT H&N), the European Organization for Research and Treatment (EORTC QLQ-H&N43), and the Orthognathic Questionnaire (OQLQ). Analyses were performed to assess differences between groups.
resultsEighty-two patients (fifty-nine men) were included. The mean age was 61.9 years. On the EORTC QLQ-H&N43, significant between-group differences (1 year vs. 5 and 10 years) were observed on five multi-item scales (mouth pain, senses, body image, anxiety, and shoulder problems) and on three single-item scales (neurological problems, neck swelling, and weight loss), indicating that QoL for those domains was more negatively impacted at 1-year post-treatment. Adjusted mean scores on most items on the EORTC QLQ-H&N43 were similar in the 5- and 10-year groups. On the other two scales (FACT H&N and OQLG), there were no significant between-group (1, 5, 10 years) differences in adjusted mean scores.
conclusionThese results show that the negative impact of H&N cancer on HRQoL is most evident at 1-year versus 5- or 10-year post-treatment. The combined administration of the EORTC QLQ-H&N43 and the OQLQ appear to provide the most useful assessment of HRQoL.
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