Evidence map›Paper›PMID 40208503›Full record

ArticleBreast cancer (Tokyo, Japan)2025

Association between preoperative grip strength and postoperative upper extremity impairments in patients with breast cancer: a retrospective cohort study.

Mayu Mizuta, Maho Okumura, Junichiro Inoue, Yuya Ueda, Shin Kondo, Mayuko Miki, Tomonari Kunihisa, Rei Ono, Yoshitada Sakai, Toshihiro Akisue

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In one paragraph

Article in Breast cancer (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Mayu MizutaDivision of Rehabilitation, Kobe University Hospital, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Maho OkumuraDivision of Rehabilitation Medicine, Kobe University Hospital International Clinical Cancer Research Center, 1-5-1, Minatojimaminamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Junichiro InoueDivision of Rehabilitation Medicine, Kobe University Hospital International Clinical Cancer Research Center, 1-5-1, Minatojimaminamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Yuya UedaDepartment of Rehabilitation Science, Kobe University Graduate School of Health Sciences, 7-10-2, Tomogaoka, Suma-ku, Kobe, Hyogo, 654-0142, Japan.
Shin KondoDivision of Rehabilitation, Tokushima University Hospital, 2-50-1, Kuramoto-cho, Tokushima, Tokushima, 770-0042, Japan.
Mayuko MikiDivision of Breast and Endocrine Surgery, Department of Surgery, Kobe University Hospital and Graduate School of Medicine, 7-5-2, Kusunoki-Cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Tomonari KunihisaDivision of Breast and Endocrine Surgery, Department of Surgery, Kobe University Hospital and Graduate School of Medicine, 7-5-2, Kusunoki-Cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Rei OnoHealth and Nutrition Department of Physical Activity Research, National Institutes of Biomedical Innovation, KENTO Innovation Park NK Bldg 3-17, Senriokashinmachi, Settu, Osaka, 566-0002, Japan.
Yoshitada SakaiDivision of Rehabilitation Medicine, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Toshihiro AkisueDepartment of Rehabilitation Science, Kobe University Graduate School of Health Sciences, 7-10-2, Tomogaoka, Suma-ku, Kobe, Hyogo, 654-0142, Japan. akisue@med.kobe-u.ac.jp.ORCID http://orcid.org/0000-0003-3708-4095

Funding

Japan Society for the Promotion of Science 22K11287
6 · The paper itself

Abstract

backgroundUpper extremity impairments in patients with breast cancer persist after curative surgery. Although postoperative factors associated with upper extremity impairments have been reported, modifiable factors affecting these impairments preoperatively remain unclear. This study aimed to investigate the relationship between preoperative grip strength and postoperative upper extremity impairments in patients with breast cancer.

methodsThis retrospective cohort study included patients (age ≥ 18 years) with breast cancer who underwent mastectomy. Maximum grip strength was measured on the day before surgery. Upper extremity impairments were assessed 4-16 months after surgery using the Disabilities of the Arm, Shoulder and Hand (DASH) scale. Multiple linear regression analysis was used to evaluate the association between preoperative grip strength and postoperative upper extremity impairments.

resultsIn total, 72 patients were included in the analysis. Multiple linear regression analysis showed that preoperative grip strength was significantly associated with the postoperative DASH score after adjusting for confounding factors (β = - 1.27, 95% confidence interval - 2.08 to - 0.48, p = 0.002).

conclusionsThis study showed that low preoperative grip strength is a risk factor for postoperative upper extremity impairments in patients with breast cancer. Providing prehabilitation to maintain and improve muscle strength immediately after diagnosis is important. Moreover, an individualized follow-up protocol according to preoperative screenings to prevent postoperative upper extremity impairments is necessary.

Indexed as

Breast NeoplasmsHand StrengthMastectomyPostoperative ComplicationsUpper ExtremityAdultAgedFemaleHumansMiddle AgedPreoperative PeriodRetrospective StudiesRisk FactorsBreast cancerGrip strengthUpper extremity impairments

Identifiers

PMID40208503
PMCPMC12174271

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