ArticleDigestive diseases and sciences2025
Unveiling Disparities in Heart Failure and Cirrhosis Related Mortality: CDC WONDER 1999 to 2020.
Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Trends in atrial fibrillation/atrial flutter and cirrhosis-related mortality in the United States from 1999 to 2020: a CDC WONDER analysis.Annals of medicine and surgery (2012) · 2026Review
- The Influence of Basic Therapy and New Drugs on NO-Dependent Mechanisms of Cardiac Destruction in Chronic Heart Failure.Biomedicines · 2026Review
- Demographic and Geographic Disparities in Atrial Fibrillation and Cirrhosis Mortality in the United States: A Twenty-Five-Year Analysis From 1999 to 2023.Cardiology research · 2026Article
- Heart of the Matter: Uncovering the Link Between Heart Failure and Cirrhosis Mortality.Digestive diseases and sciences · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with heart failure and cirrhosis are a highly vulnerable population due to increased risk of morbidity and mortality. There is limited evidence on mortality trends by age, sex, race, and geographic location in contemporary years in this vulnerable population.
methodsMultiple cause of death files from the Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research from 1999 to 2020 in age ≥ 25 years were used. Death was presented as age-adjusted mortality rates (AAMR) per 100,000 population. Joinpoint Trend Analysis Software was used to determine annual percentage change (APC). These were stratified by age, sex, race and ethnicity, location of death (medical facilities, home, hospice, nursing home), regions (Northeast, Midwest, South, and West), states, and rural-urban areas.
resultsTotal deaths were 98,530 and AAMR was 2.05. The APC from 2001 to 2009 was - 2.80, but from 2009 to 2014 was + 3.16, 2014 to 2018 was + 7.88, and 2018 to 2020 was + 12.23. AAMR were higher in non-Hispanic American Indians (NHAI) (4.11), with a sharp rise in mortality (APC + 14.58, 2013 to 2020). Higher AAMR were observed in the South (2.23) and West (2.24), West Virginia (3.45) and Oklahoma (3.23), rural areas (2.52), males (2.86), and age ≥ 75 years (9.61). Most deaths took place inpatient (48,255).
conclusionThere was an initial decline in mortality, however, a rise was observed in recent years. NHAI have the highest AAMR. Higher AAMR are observed in males, in the South and West, and in rural areas. We emphasize the need for targeted interventions addressing these disparities by improving access to resources, surveillance, and management strategies for this vulnerable population.
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