ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Optimizing the Elecsys
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The trial behind it
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Authors and funding
7 authors.
Funding
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Abstract
purposeViral hepatitis remains a leading cause of infectious mortality worldwide. This study aimed to improve the serological screening process by reducing unnecessary testing and healthcare costs by optimizing the assay threshold.
methodsThree methods (Elecsys
resultsThe Alinity s Anti-HCV II assay showed the highest sensitivity (100%) and specificity (98.2%). This assay was used to establish the cut-off threshold for our method. The best Youden's index was obtained with a value of 17.8 (sensitivity (95.6%), specificity (96.4%)). In a retrospective cohort of 667 patients with a positive initial HCV screening, 124 had an S/CO ratio of ≤ 17.8. Of these, Vidas
conclusionsAn S/CO cut-off of 17.8 was established for the Elecsys
Indexed as
Identifiers
40208489What OpenQuestion holds
Registered trials
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