Evidence map›Paper›PMID 40208483›Full record

ArticleGenes & genomics2025

RalB promotes lymph node metastasis in tongue squamous cell carcinoma.

Yuman Zhang, Jiali Yang, Yi Gong, Zhihan Liu, Yanguang Yang, Xiaoyong Song, Yuting Gao, Yajun Xiong, Dan Wang, Kai Fu and 2 more

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In one paragraph

Article in Genes & genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yuman ZhangDepartment of Otolaryngology Head and Neck Surgery, Chongqing General Hospital, Chongqing, 401147, China.
Jiali YangDepartment of Pathobiology and Immunology, Hebei University of Chinese Medicine, Shijiazhuang, 050200, China.
Yi GongLaboratory of Integrated Medicine Tumor Immunology, Shanxi University of Chinese Medicine, Taiyuan, 030000, China.
Zhihan LiuLaboratory of Integrated Medicine Tumor Immunology, Shanxi University of Chinese Medicine, Taiyuan, 030000, China.
Yanguang YangDepartment of Pathobiology and Immunology, Hebei University of Chinese Medicine, Shijiazhuang, 050200, China.
Xiaoyong SongLaboratory of Integrated Medicine Tumor Immunology, Shanxi University of Chinese Medicine, Taiyuan, 030000, China.
Yuting GaoLaboratory of Integrated Medicine Tumor Immunology, Shanxi University of Chinese Medicine, Taiyuan, 030000, China.
Yajun XiongLaboratory of Integrated Medicine Tumor Immunology, Shanxi University of Chinese Medicine, Taiyuan, 030000, China.
Dan WangLaboratory of Integrated Medicine Tumor Immunology, Shanxi University of Chinese Medicine, Taiyuan, 030000, China.
Kai FuDepartment of Otolaryngology Head and Neck Surgery, The Fourth Hospital of Hebei Medical University, 12# Jiankang Road, Shijiazhuang, 050000, Hebei Province, China. fukaisk@163.com.
Lifeng JiaDepartment of Otolaryngology Head and Neck Surgery, Chongqing General Hospital, Chongqing, 401147, China. lfjwwb@126.com.
Xinli ShiDepartment of Otolaryngology Head and Neck Surgery, Chongqing General Hospital, Chongqing, 401147, China. shixinli@sxtcm.edu.cn.ORCID 0000-0003-1164-1156

Funding

Medical research topic of Hebei Province Health Commission 20230135Science and Health Joint Project of Chongqing 2020ZY013586
6 · The paper itself

Abstract

backgroundLymph nodes metastasis is the main metastasis mode of tongue squamous cell carcinoma (TSCC). Ras related GTP binding protein B (RalB) have been recently described that it was involved in tumor growth and metastasis, but the effect in TSCC is still ill-defined.

objectiveThis study provides insights into the role of RALB as a prognostic factor in head and neck squamous cell carcinoma (HNSCC) and demonstrates its involvement in promoting lymph node metastasis in TSCC.

methodsFirstly, the expression level of RALB and the relationship with clinical features were examined. Subsequently, RALB knockdown Cal-27 cells orthotopic xenotransplantation in the tongue of BALB/c nude mice were established. Finally, using Connectivity Map (CMAP) database to find possible drugs.

resultsFirstly, RALB could not only predict the cancer patients' prognosis and survival and but also act as a potential prognostic factor, particularly in HNSCC by pan-cancer bioinformatics analysis. In addition, we found that RalB promoted tumor growth and lymph node metastasis. Finally, we identified Tirabrutinib (ONO-4059) targeting RalB with good binding properties.

conclusionsRalB act as a prognostic gene in HNSCC, and promote lymph node metastasis in early stage of TSCC.

Indexed as

Carcinoma, Squamous Cellral GTP-Binding ProteinsSquamous Cell Carcinoma of Head and NeckTongue NeoplasmsAnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansLymphatic MetastasisMaleMiceMice, Inbred BALB CMice, NudeMiddle AgedRalb protein, humanral GTP-Binding ProteinsLymph node metastasisRALBTirabrutinibTongue squamous cell carcinoma

Identifiers

PMID40208483

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.