ReviewClinical journal of gastroenterology2025
A case of an alpha-fetoprotein-producing intrahepatic cholangiocarcinoma.
Review in Clinical journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alpha-fetoprotein is a well-known marker of hepatocellular carcinoma. Alpha-fetoprotein-producing intrahepatic cholangiocarcinoma is rare. This report detailed our experience with such a case and reviewed the relevant literature. A 71-year-old man underwent dynamic computed tomography, which revealed a 40-mm hepatic mass in S6 with early arterial phase enhancement and delayed phase washout. Analysis of tumor markers revealed elevated alpha-fetoprotein levels. Positron emission tomography-computed tomography indicated a maximum standardized uptake value of 3.70. Presuming hepatocellular carcinoma, we performed a laparoscopic subsegmentectomy of S6. However, immunohistochemical examination revealed that the tumor was cytokeratin 7- and cytokeratin 19-positive, whereas the Hepatocytes and glypican-3 were negative, with some cells expressing alpha-fetoprotein, leading to a final diagnosis of alpha-fetoprotein-producing intrahepatic cholangiocarcinoma. After surgery, the patient was followed up without postoperative adjuvant chemotherapy at his request. Six months later, the patient's alpha-fetoprotein level increased again, and computed tomography revealed multiple intrahepatic and lung metastases. Chemotherapy was subsequently initiated. Six courses were administered; however, the disease gradually worsened, and the patient died 13 months after surgery. Differentiating between hepatocellular carcinoma and intrahepatic cholangiocarcinoma is crucial because of divergent postoperative treatments. Although rare, alpha-fetoprotein-producing intrahepatic cholangiocarcinoma should be considered in liver tumors, even with isolated alpha-fetoprotein elevation.
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