ArticleThe international journal of cardiovascular imaging2025
Left ventricular diastolic inflow and myocardial flow reserve in patients with coronary artery disease: simultaneous analysis of 4D-Flow and myocardial perfusion using hybrid PETMR.
Article in The international journal of cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aimed to simultaneously evaluate the association between diastolic left ventricular (LV) inflow and myocardial flow reserve (MFR) using a hybrid PET/MR system in patients with coronary artery disease (CAD).
methodsSixty-seven patients (mean 66 ± 15 years, male 55) with CAD who underwent rest-pharmacological stress
resultsIn all patients, diastolic LV inflow parameters significantly increased in the stress scan compared to the rest (53.7 ± 23.1 vs. 64.1 ± 32.9 ml/s, p = 0.0002; 68.1 ± 15.1 vs. 76.4 ± 20.6 cm/s, p = 0.0001 for LVinf and peakV, respectively). PeakV and PFR showed a significant correlation for rest and stress (r = 0.4, p = 0.01; r = 0.3, p = 0.03 for rest and stress, respectively).ΔpeakV significantly correlated to stress MBF, and MFR (r = 0.3, p = 0.007; r = 0.3, p = 0.04 for stress MBF, and MFR, respectively). Among patients with preserved LVEF (n = 47), when were divided into 4 subgroups based on the median myocardial flow reserve (MFR, 1.86) and the presence of perfusion defect, ΔpeakV was significantly higher in those with MFR above median and without abnormal perfusion compared to the other groups (21.8 ± 13.6 vs. 13.5 ± 17.0, 13.0 ± 13.5, and 4.6 ± 19.1; p = 0.04, 0.04, and 0.04 for MFR ≥ 1.86 or < 1.86 with or without abnormal perfusion, respectively).
conclusionNon-invasive assessment of diastolic intra-LV hemodynamics derived from 4D flow MR demonstrated a significant association with coronary vasodilation.
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