Evidence map›Paper›PMID 40208393›Full record

ArticleInternational ophthalmology2025

Survey of eye patients' serum for biomarkers of primary open angle glaucoma in Gwagwalada, Nigeria: serum biomarkers for primary open angle glaucoma.

Abdulkabir Ayansiji Ayanniyi, Abdulraheem Olarongbe Mahmoud, Yetunde Olamide JohnSam, Rauf Ibrahim Rauf, David Paul Ejeba, Rosita Ujunwa Akasike-Enuh, Jessica Osarumwense Oviasu, Maxwell Madueke Nwegbu

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Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Abdulkabir Ayansiji AyanniyiDepartment of Ophthalmology, University of Abuja, PMB 117, Abuja, Nigeria. abdulkabir.ayanniyi@uniabuja.edu.ng.
Abdulraheem Olarongbe MahmoudDepartment of Ophthalmology, University of Ilorin, Ilorin, Nigeria.
Yetunde Olamide JohnSamDepartment of Ophthalmology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.
Rauf Ibrahim RaufDepartment of Statistics, University of Abuja, PMB 117, Abuja, Nigeria.
David Paul EjebaDepartment of Ophthalmology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.
Rosita Ujunwa Akasike-EnuhDepartment of Ophthalmology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.
Jessica Osarumwense OviasuJessica Osarumwense Oviasu, University Health Services, University of Abuja, Abuja, Nigeria.
Maxwell Madueke NwegbuDepartment of Chemical Pathology, University of Abuja, PMB 117, Abuja, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine and compare serum parameters of primary open angle glaucoma (POAG) patients with that of non-glaucoma eye patients towards discovering biomarkers for POAG.

methodsThe fasting blood of 235 adult eye patients including 96 POAG and 139 non-glaucoma was collected, processed and serum analysed for urea and creatinine, electrolytes, enzymes, protein, bilirubin and lipids.

resultsTwo hundred and thirty-five adult participants of 42 ethnics including 96 with POAG and 139 non-glaucoma were studied. The age range was 19-85 (mean 53.70±13.15 POAG; 46.05±14.00 non-glaucoma) years and (114/235, 48.5%) were males. The mean serum parameters for POAG versus (v) non-glaucoma include Urea 37.04SE2.46 v 27.01SE1.00, P = 0.000; Creatinine 1.08SE0.16 v 1.68SE0.15, P = 0.007; Chloride 86.47SE2.91 v 78.63SE1.43, P = 0.017; Sodium 140.16SE3.82 v 124.83SE3.17, P = 0.953; Potassium 4.70SE0.19 v 4.67SE0.25, P = 0.29; Alkaline Phosphatase (ALP) 17.47SE1.93 v 93.09SE13.87, P = 0.000; Alanine Aminotransferase (ALT) 3.33SE0.61 v 14.95SE1.49, P = 0.000; Aspartate aminotransferase (AST) 16.90SE1.57 v 21.37SE7.85, P = 0.258; Total protein 5.60SE0.15 v 6.03SE0.09, P = 0.015; Albumin 3.26SE0.09 v 3.28SE0.05, P = 0.83; Globulin 2.34SE0.15 v 2.75SE0.09, P = 0.020; Direct bilirubin 0.61SE0.04 v 0.57SE0.04, P = 0.32; Total bilirubin 0.53SE0.06 v 0.90SE0.16, P = 0.14; Cholesterol 169.39SE6.30 v 214.17SE4.60, P = 0.078; High Density Lipoprotein (HDL) 49.53SE2.58 v 45.11SE0.76, P = 0.104, and Triglyceride 80.12SE4.79 v 91.44 SE3.84, P = 0.271.

conclusionThe serum urea, creatinine, chloride, alkaline phosphatase, alanine aminotransferase, total protein, and globulin showed high potential as biomarkers for primary open angle glaucoma. These serum parameters should be further investigated to determine their specificity for primary open angle glaucoma.

Indexed as

BiomarkersGlaucoma, Open-AngleIntraocular PressureAdultAgedAged, 80 and overCreatinineFemaleHumansLipidsMaleMiddle AgedNigeriaYoung AdultBiomarkersCreatinineLipidsGwagwaladaNigeriaPrimary open angle glaucomaSerum biomarkers

Identifiers

PMID40208393

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.