Trial reportClinical oral investigations2025
Tooth sensitivity and whitening effect of an in-office bleaching gel containing 2% sodium fluoride: a randomized triple-blind clinical trial.
Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Evaluating the Efficiency and Tooth Sensitivity of a Novel Whitening Strip: A Randomized, Double-Blind Controlled Trial.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Trial
- Tooth-Whitening Agents and Polymer-Based Carriers: Efficacy, Safety, and Clinical Perspectives.Polymers · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to evaluate effect of adding sodium fluoride (NaF) to the in-office bleaching gel on bleaching sensitivity (BS) and tooth whitening. MATERIALS AND
methodsTwo maxillary quadrants from 32 patients were randomly allocated to intervention and control groups in a split-mouth design. In control group, bleaching gel containing 40% hydrogen peroxide and in intervention group, the same gel with 2% NaF were applied for 45 min. Before treatment, immediately, 24 h, 7d, 30d and 90d after treatment, sensitivity to cold, touch and spontaneous stimuli was measured through Visual Analogue Scale (VAS). Color changes were evaluated by a spectrophotometer and reported through ΔE and ΔSGU values. Data were analyzed by Shapiro-Wilk, 2Q AZMann-Whiteny U, Friedman and Wilcoxon tests (α = 0.05).
resultsA total of 29 patients completed the study. The cold and spontaneous sensitivity significantly decreased from baseline until 90d post-bleaching in both groups (P < 0.001), while a significant decline in tactile sensitivity demonstrated only in NaF group (p = 0.01). In the comparison between two groups, only the cold sensitivity was significantly lower in NaF group at 90d after bleaching (p = 0.040). There was no significant difference between two groups in ΔE/ΔSGU values at any of evaluation intervals.
conclusionsThe incorporation of 2% NaF into the bleaching gel significantly reduced cold sensitivity after 90d, with no detrimental effects on whitening effectiveness. (IRCT20200906048639N1) CLINICAL RELEVANCE: The in-office bleaching gel containing 2% NaF did not demonstrate a beneficial impact on BS. Nonetheless, it did not negatively affect the results of tooth whitening.
Indexed as
Identifiers
40208369What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.