Hyaluronic acid delayed filler complications: a racial group analysis and call to action.

Andrea Quartey, Udokama Ezekwe, Valerie Callender

Abstract readReview

In one paragraph

Review in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Safety and Effectiveness of a Crosslinked Hyaluronic Acid Filler in Korean Patients for the Correction of Nasolabial Folds: A Randomized, Patient- and Evaluator-Blinded, Paired Study.Aesthetic surgery journal · 2026
Trial

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrea QuarteyLewis Katz School of Medicine, Temple University, Philadelphia, PA, United States of America. quarteyandrea@gmail.com.

Udokama EzekweLewis Katz School of Medicine, Temple University, Philadelphia, PA, United States of America.

Valerie CallenderHoward University College of Medicine, Washington, DC, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injectable cosmetic treatments, especially hyaluronic acid (HA) fillers, constitute over 90% of cosmetic procedures in the U.S. These fillers can cause delayed complications in patients. Given the structural differences in skin of color (SOC) patients compared to those with lighter skin types, this study aims to report the incidence of these complications across different racial and skin types. This study reviewed published literature examining delayed complications of hyaluronic acid fillers occurring across different races, ethnicities, and skin types. A PubMed search in April 2024 identified studies using specific search terms related to HA fillers and delayed complications. A limited number of articles discussed race, ethnic background or skin type when reporting HA delayed filler complications. The literature reflected differences in the rates at which AEs were reported based on patient reported race. However, to determine the true incidence of HA delayed filler complications across race and ethnic backgrounds, efforts should be made to include full demographic information in reporting these events in the literature.

Indexed as

Cosmetic TechniquesDermal FillersHyaluronic AcidSkin AgingEthnicityHumansIncidenceRacial GroupsSkin PigmentationTime FactorsUnited StatesDermal FillersHyaluronic AcidDelayed complications of fillerFitzpatrick skin type, race reportingHyaluronic acid fillerSkin of color

Identifiers

PMID40208361

DOI10.1007/s12026-017-8980-5

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.