Evidence map›Paper›PMID 40208352›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Resistance exercise dose effects on muscle morphology, muscle function and quality of life in advanced-stage ovarian cancer survivors.

Christelle Schofield, Marit Mol, Dennis R Taaffe, Laurien M Buffart, Pedro Lopez, Robert U Newton, Daniel A Galvão, Paul A Cohen, Carolyn J Peddle-McIntyre

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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christelle Schofield *Exercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia.
Marit Mol *Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Dennis R TaaffeExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia.
Laurien M BuffartExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia.
Pedro LopezGrupo de Pesquisa Em Exercício Para Populações Clínicas (GPCLIN), Universidade de Caxias Do Sul, Caxias Do Sul, Rio Grande Do Sul, Brazil.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia.
Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia.
Paul A CohenWestern Australian Gynaecological Cancer Service, King Edward Memorial Hospital, Perth, Western Australia, Australia.
Carolyn J Peddle-McIntyreExercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia. c.mcintyre@ecu.edu.au.ORCID http://orcid.org/0000-0001-6322-0287

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimAdvanced-stage ovarian cancer survivors often have compromised muscle morphology (muscle mass and density), muscle function (muscle strength and physical function), and health-related quality of life (HRQoL). We recently reported improvements in these outcomes following resistance training. Information on the resistance exercise dose required to improve health-related outcomes is still lacking in this cancer group. Here we examined the exercise dose delivered and the effect of the delivered dose on changes in outcomes of interest.

methodsTwelve women with stage III or IV ovarian cancer completed a 12-week supervised resistance exercise intervention. Exercise metrics included compliance (exercise dose completed), dose modifications (sessions modified) and tolerance (rating of perceived exertion; RPE). Participants were allocated to lower (< 63%) or higher (> 63%) exercise compliance based on median split. Differences in change to muscle morphology, muscle function and HRQoL between compliance groups were investigated.

resultsMedian compliance and session RPE were 63.0% and 13 (somewhat hard), respectively. Dose reductions occurred in 92.7% of sessions. Both groups experienced improvements in muscle morphology and function. Higher compliance was associated with greater improvements in whole body lean mass (+ 1.3 kg vs. + 0.5 kg) and lower body strength (+ 50 kg vs. + 13 kg). Only the lower compliance group experienced a clinically significant improvement in 400-m walk time (-48.4 s vs. -9.4 s). Both groups experienced clinically meaningful improvements in social and cognitive functioning.

conclusionRelatively lower doses of resistance exercise may benefit advanced-stage ovarian cancer survivors. Exercise programs may need to be flexible and individualized to fit the needs of this cancer group.

Indexed as

Cancer SurvivorsMuscle, SkeletalOvarian NeoplasmsQuality of LifeResistance TrainingAdultAgedFemaleHumansMiddle AgedMuscle StrengthNeoplasm StagingPatient ComplianceAdvanced ovarian cancerExercise doseMuscle morphologyResistance exercise

Identifiers

PMID40208352
PMCPMC11985650

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.