Observational studyArchives of dermatological research2025
Adalimumab combination with corticosteroid therapy for Stevens-Johnson syndrome/toxic epidermal necrolysis.
Observational study in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Nursing care of an elderly patient with toxic epidermal necrolysis: a case report.Frontiers in medicine · 2026Article
- Upadacitinib Coadministered with Methylprednisolone for Effective Treatment of SJS/TEN Overlap Syndrome: A Case Report.Clinical, cosmetic and investigational dermatology · 2025Article
- Predictive value of a severity-of-illness score for toxic epidermal necrolysis (SCORTEN) factors for in-hospital mortality in Stevens-Johnson syndrome/toxic epidermal necrolysis.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a severe acute mucocutaneous reactions associated with considerable mortality and poor prognosis. Corticosteroids and intravenous immunoglobulin (IVIG), as a traditional remedy, have been widely used in the treatment of SJS/TEN. Recent studies have reported the potential therapeutic benefits of tumor necrosis factor-alpha (TNF-α) antagonists on the disease. However, the optimal treatment remains unknown. This study is to compare the effectiveness and safety of TNF-α antagonist adalimumab conjunction with corticosteroid to traditional remedy on SJS/TEN. In this single-center, retrospective, observational study, we enrolled 53 SJS/TEN patients received either traditional remedy (Corticosteroids and IVIG) or a combination therapy (TNF-α antagonist conjunction with corticosteroid). The primary endpoint was duration of hospitalization and re-epithelization time, and the secondary endpoints including exposure time to high-dose steroids, and major adverse event incidence. 26 patients received traditional remedy and 27 patients received combination remedy. In comparison to traditional remedy, the combination remedy reduced the hospitalization duration (25 ± 4.7 vs. 22 ± 5.2 days; P = 0.032), re-epithelization time (19 ± 2.5 vs.17 ± 3.4 days; P = 0.019), and exposure time to high-dose steroids (18 ± 4 vs. 16 ± 2 days; P = 0.025). Obviously, TNF-α levels in the combination group showed a significant decreased on the discharge day comparing to the traditional group (3.9 ± 1.8 vs. 5.8 ± 2.2, p = 0.001). The major adverse event incidences were no significant statistically difference (P > 0.05) within 6 months of follow-up after hospital discharge, and no death happened between two groups. The combination remedy (adalimumab conjunction with corticosteroid) could be an optimal treatment to promote disease recovery without increasing adverse events and morality in SJS/TEN patients.
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