Evidence map›Paper›PMID 40208300›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2025

C-reactive protein-to-albumin ratio is associated with mortality after transcatheter tricuspid valve repair.

Karl Finke, Laura Marx, Jan Althoff, Thorsten Gietzen, Matthieu Schäfer, Jan Wrobel, Philipp von Stein, Jennifer von Stein, Maria Isabel Körber, Stephan Baldus and 2 more

Abstract read
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In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. C-reactive protein-to-albumin ratio in transcatheter tricuspid valve repair: methodological concerns and ınconsistencies.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karl FinkeFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany. Karl.finke@uk-koeln.de.ORCID http://orcid.org/0000-0002-4710-8508
Laura MarxFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Jan AlthoffFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Thorsten GietzenFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Matthieu SchäferFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Jan WrobelFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Philipp von SteinFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Jennifer von SteinFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Maria Isabel KörberFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Stephan BaldusFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Roman PfisterFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Christos IliadisFaculty of Medicine, Department III of Internal Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscatheter tricuspid valve repair (TTVr) is a treatment option for tricuspid regurgitation (TR) in patients with high surgical risk. Given the heterogeneity in clinical benefit, there is a need for markers to assess mortality risk in patients undergoing TTVr. The C-reactive protein (CRP)/albumin ratio (CAR) is a marker of systemic inflammation and reduced nutritional status, which can both occur in TR.

methodsConsecutive patients undergoing TTVr at a tertiary care center were retrospectively analyzed. Serum CRP and albumin were collected at baseline. Intraprocedural success (IS) was defined according to TVARC criteria. The primary outcome of all-cause mortality was assessed up to 2 years after TTVr.

resultsA total of 215 patients (69% females, median age 80 years) were identified. IS was achieved in 61% of patients. AUC of CAR for 2-year mortality was 0.695, with an optimal threshold of 1.2945 (Youden index) dividing patients in high CAR (n = 93) and low CAR (n = 122) groups. In the high CAR group, the primary endpoint occurred more frequently (43% vs 15%, p < 0.001) and significantly higher right atrial pressure, worse renal function, and less IS during TTVr were observed. High CAR was independently associated with an increased mortality risk even when adjusted for renal and liver function, right-ventricular function, and procedural failure (HR 2.188; 95%CI 1.2-3.9; p = 0.011).

conclusionHigher CAR reflects patients with advanced right-heart failure and extracardiac organ damage and is associated with mortality after TTVr. CAR is derived from readily available parameters and may be useful additive to established risk scores.

Indexed as

Cardiac CatheterizationC-Reactive ProteinHeart Valve Prosthesis ImplantationSerum AlbuminTricuspid ValveTricuspid Valve InsufficiencyAgedAged, 80 and overBiomarkersFemaleFollow-Up StudiesHumansMaleRetrospective StudiesRisk AssessmentRisk FactorsBiomarkersC-Reactive ProteinSerum AlbuminBiomarkerInflammationMalnutritionRight heart failureTranscatheter tricuspid valve repairTricuspid regurgitation

Identifiers

PMID40208300
PMCPMC12202701

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.