ArticleAbdominal radiology (New York)2025
Improving radiologists' diagnostic accuracy for lymphovascular invasion in colorectal cancer: insights from a multicenter CT-based study.
Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- RadiolGAN: Multicenter Feasibility Study of Synthetic CT From 3D Ultra-Short Echo Time MRI for Enhanced Pulmonary Radiologic Sign Visualization.Journal of magnetic resonance imaging : JMRI · 2026Article
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13 authors.
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Abstract
backgroundThe current standard of subjective assessment by radiologists for lymphovascular invasion (LVI) in colorectal cancer (CRC) using CT images often falls short in diagnostic accuracy. This study introduces an advanced CT-based prediction model aimed at providing support for radiologists' assessment to accurately diagnose LVI.
methodsWe conducted a retrospective analysis of 1409 patients with pathologically confirmed CRC from four institutions. Radiomics features were extracted from tumor areas on CT images, and Deep Residual Shrinkage Networks with Channel-wise Thresholds (DRSN-CW) algorithm was utilized to build prediction model. We assessed the model's impact on enhancing radiologists' diagnostic performance and employed Shapley Additive Explanation (SHAP) to interpret the influence of key features on predictions.
resultsThe prediction model achieved strong prediction performance with AUCs of 0.896 (95% CI: 0.866-0.923), 0.849 (0.782-0.908), 0.845 (0.782-0.901) and 0.799 (0.709-0.881) in the training and validation cohorts. Crucially, when informed by the model, radiologists demonstrated a significant improvement in diagnosing LVI. SHAP analysis provided detailed insights into the model's decision-making process, enhancing its clinical relevance. We also observed that patients predicted to be LVI-negative by the model had significantly longer overall survival (OS) compared to those LVI-positive (training cohort, p = 0.012; internal validation cohort, p = 0.046).
conclusionsThis study introduces a CT-based prediction model that significantly enhances radiologists' ability to accurately diagnose LVI in CRC. By improving diagnostic accuracy and demonstrating the association between LVI predictions and OS, the model provides a valuable tool for clinical decision-making, with the potential to improve patient outcomes.
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