Evidence map›Paper›PMID 40207915›Full record

ArticlemBio2025

Fecal microbiota transplants (FMT) of three distinct human communities to germ-free mice exacerbated inflammation and decreased lung function in their offspring.

Ivon A Moya Uribe, Hinako Terauchi, Julia A Bell, Alexander Zanetti, Sanket Jantre, Marianne Huebner, S Hasan Arshad, Susan L Ewart, Linda S Mansfield

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Acepromazine Reduces Airway Contraction in a Murine Model of Asthma.Clinical and experimental pharmacology & physiology · 2026
    Article
  2. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ivon A Moya UribeComparative Enteric Diseases Laboratory, Michigan State University, East Lansing, Michigan, USA.
Hinako TerauchiComparative Enteric Diseases Laboratory, Michigan State University, East Lansing, Michigan, USA.
Julia A BellComparative Enteric Diseases Laboratory, Michigan State University, East Lansing, Michigan, USA.
Alexander ZanettiComparative Enteric Diseases Laboratory, Michigan State University, East Lansing, Michigan, USA.
Sanket JantreDepartment of Statistics and Probability, Michigan State University, East Lansing, Michigan, USA.
Marianne HuebnerDepartment of Statistics and Probability, Michigan State University, East Lansing, Michigan, USA.
S Hasan ArshadClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Susan L EwartCollege of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Linda S MansfieldComparative Enteric Diseases Laboratory, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-7523-7577

Funding

Transgenerational epigenetic inheritance of allergy in a multigenerational cohortR01AI091905 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KARMAUS, WILFRIED JJ · 2011 to 2015
$2.7M
Short-term biomedical research training program for veterinary studentsT35OD016477 · OD · MICHIGAN STATE UNIVERSITY · PI COLLEEN Cosgrove HEGG, Andrea Noel Johnston · 2013 to 2026
$1.5M
Defining the role of the early infant microbiome in mediating allergic outcomes associated with asthma in a mouse modelR21AI121748 · NIAID · MICHIGAN STATE UNIVERSITY · PI EWART, SUSAN L, MANSFIELD, LINDA S. · 2016 to 2017
$426k
Albert C. and Lois E. Dehn Endowment RN031097-DEHNHHS | National Institutes of Health (NIH) R01AI091905HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI121748Michigan State University Discretionary Funds RG072646 Mansfield DFINIAID NIH HHS R01 AI091905NIAID NIH HHS R21 AI121748NIH HHS T35 OD016477University Distinguished Professor Endowment GS100019MAN
6 · The paper itself

Abstract

Despite explosive rise in allergies, little is known about early life gut microbiota effects on postnatal respiratory function. We hypothesized that IMPORTANCE: Fecal microbiota transplants (FMT) of three distinct human communities to germ-free mice exacerbated inflammation and decreased lung function in their offspring. Taxa formerly described to induce an allergic response (agonists) and pro-inflammatory taxa were abundant in

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeInflammationLungAnimalsFemaleGerm-Free LifeHumansInfantMaleMiceMice, Inbred C57BLairway hyperresponsiveness (AHR)allergyasthmaeczemafecal microbiota transplant (FMT)lung functionmurine model

Identifiers

PMID40207915
PMCPMC12077122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.