Evidence map›Paper›PMID 40207817›Full record

ReviewCurrent neuropharmacology2025

Anticholinesterases Traits Inbuilt in

Jiri Patocka, Srishti Sharma, Zdenka Navratilova, Namrata Singh, Romana Jelinkova, Nigar Mehboob, Patrik Oleksak, Eugenie Nepovimova, Kamil Kuca

Abstract readReview
In one paragraph

Review in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiri PatockaInstitute of Radiology, Faculty of Health and Social Studies, Toxicology and Civil Protection, University of South Bohemia Ceske Budejovice, Ceske Budejovice, Czech Republic.
Srishti SharmaSchool of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, (C.G.), 492010, India.
Zdenka NavratilovaDepartment of Botany, Faculty of Science, Charles University, Prague, Czech Republic.
Namrata SinghRamrao Adik Institute of Technology, DY Patil University, Nerul, Navi Mumbai, India.
Romana JelinkovaNBC Defence Institute, University of Defence, Vyskov, Czech Republic.
Nigar MehboobDepartment of Pharmacy, School of Pharmacy, DY Patil University, Navi Mumbai, Maharashtra, 400706, India.
Patrik OleksakDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Eugenie NepovimovaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Kamil KucaBiomedical Research Centre, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.

Funding

UHK PrF Excellence Project 2208/2024-2025, CZ.10.03.01/00/22_003/0000048, FIM UHK 2203
6 · The paper itself

Abstract

This review provides a comprehensive account of advances in the field of cholinesterase inhibitors isolated from the Buxaceae family. Naturally occurring anticholinesterases derived from plants are considered to be a potential source of new drug candidates for treating Alzheimer's disease (AD). AD is now universally accepted as an irreversible, incurable, and progressive neurological disorder. Initiating with memory impairment, propagating with cognitive deficit, and ultimately leading to death is the general pathway of AD. Lower level of acetylcholine in the brain is characterized as one of the prominent reasons for AD. The cholinergic hypothesis states that elevated levels of acetylcholine in the brain can alleviate symptoms of AD. Steroidal and terpenoidal alkaloids isolated from plants of the Buxaceae family have been reviewed here for their anticholinesterase activity. Most of them have shown

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsPlant ExtractsAnimalsHumansCholinesterase InhibitorsPlant ExtractsacetylcholinesteraseAlzheimer’s diseasebutyrylcholinesterase.Buxaceaecholinesterase inhibitorsinhibition

Identifiers

PMID40207817
PMCPMC12307989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.