ArticleCurrent topics in medicinal chemistry2025
Ovothiol-A Exhibited Protective and Therapeutic Effect against Hyperthyroidism in Rats.
Article in Current topics in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Natural Histidine Derivatives-From Basic Research to Potential Applications in Cosmetics and Nutricosmetics.Antioxidants (Basel, Switzerland) · 2026Review
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Authors and funding
3 authors.
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Abstract
introduction2.5% of adults worldwide suffer from hyperthyroidism, which is associated with osteoporosis, heart disease, and increased mortality.
aimThe current study evaluates the protective and therapeutic effect of Ovothiol A on Thyroxineinduced hyperthyroidism in rats.
methodsExperimental animals were split into two categories: protective and curative. Each group was further separated into three subgroups (6 per group): control, hyperthyroidism (HT), and Ovothiol-A (250 mg/kg). Thyroxine hormone (600 mg/kg) is administered orally to rats to induce HT.
resultsOvothiol-A supplementation resulted in significant decreases in organ weight index, T3, T3,T4, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, malondialdehyde, nitric oxide levels, and tumour necrosis factor-alpha while increasing in body weight, TSH, glutathione reduced, catalase, and glutathione-S-transferase levels. Histopathological investigation revealed significant thyroid and liver tissue improvements, significantly reducing collagen deposition.
conclusionOvothiol-A exhibited protective and therapeutic effects against hyperthyroidism in rats. Ovothiol-A exhibits antithyroid activity by stimulating the antioxidant system, reducing inflammation, and restoring thyroid hormone levels.
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Registered trials
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