ArticleEuropean journal of neurology2025
Voxel-Based Lesion Symptom Mapping to Predict Poststroke Epilepsy After Mechanical Thrombectomy.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Targeting Neuroinflammation in the Piriform Cortex-Amygdala: Enhanced Efficacy of Niosome-Based Sodium Butyrate in Ischemic Stroke.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Article
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10 authors.
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Abstract
introductionPoststroke epilepsy (PSE) is an important long-term complication after stroke. Data regarding predictors of PSE in patients with large-vessel occlusion stroke receiving mechanical thrombectomy (MT) are scarce. Voxel-based lesion symptom mapping on brain MRI might be a valuable tool in the risk prediction of PSE. This study aims to assess PSE risk after acute stroke treated with MT via voxel- and volumetric-based analyses.
methodsIn this bi-center study from two tertiary-care stroke centers, we included consecutive acute ischemic stroke patients who had received MT between 2011 and 2017, and had postinterventional brain MRI as well as long-term follow-up data available. Infarct volume and location were assessed on MRI. Following semiautomated lesion outlining and generation of binarized lesion masks, lesion symptom mapping was applied to identify relevant topographical lesion patterns in PSE.
resultsOf 348 analyzed patients, 97 cases had to be excluded due to insufficient image quality and inaccurate registration results. Finally, lesion maps from 251 patients (median age: 66, 45.4% women) were considered for lesion symptom mapping, including maps from 26 patients with PSE (10.4%). Mean infarct volume was higher in PSE patients (119.2 cm
conclusionApart from infarct volume, lesion symptom mapping on postinterventional brain MRI identified specific brain regions associated with PSE after large vessel occlusion stroke. This information might be helpful for PSE risk stratification and follow-up care in this specific population.
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