ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Residual periodic limb movement index after CPAP therapy is associated with hypoxemia.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- When legs move and airways close: kicking up an old controversy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Nocturnal hypoxemia in COPD: the amplifying effect of comorbid OSA and PLMS on oxygen desaturation.Therapeutic advances in respiratory diseaseArticle
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5 authors.
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Abstract
STUDY
objectivesPeriodic limb movements during sleep frequently coexist with obstructive sleep apnea, yet the impact of continuous positive airway pressure treatment on periodic limb movements during sleep remains unclear. This study investigated factors associated with persistence of periodic limb movement index (PLMI) during continuous positive airway pressure therapy.
methodsA retrospective cross-sectional study analyzed data from 107 adult patients who underwent split polysomnographic studies. Participants were classified into 4 groups based on PLMI changes: normal PLMI throughout (group 1), persistent elevated PLMI (group 2), worsened PLMI (group 3), and resolved PLMI (group 4). Predictors of PLMI persistence, including sleep architecture, oxygen desaturation, age, and body mass index, were assessed using logistic regression analysis.
results36.1% of patients experienced resolution of elevated PLMI, 16.4% showed worsening, and 47.5% had persistent PLMI despite continuous positive airway pressure therapy. Logistic regression analysis revealed that male sex (odds ratio = 5.38, 95% confidence interval = 1.64-17.61,
conclusionsResidual periodic limb movements during continuous positive airway pressure therapy are common and are independently associated with male sex, higher body mass index, and greater hypoxemia during the diagnostic portion of sleep. CITATION: DelRosso LM, Modi H, Jain V, Vazquez IM, Picchietti DL. Residual periodic limb movement index after CPAP therapy is associated with hypoxemia.
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