Evidence map›Paper›PMID 40207533›Full record

Trial reportJournal of the American Heart Association2025

Collateral Circulation and

Kun Zhang, Luji Liu, Tong Li, Rui Wang, Kailin Bu, Pandi Zhao, Xiaoyun Liu

Registry-linked trialAbstract readClinical Trial, Phase IV
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04091412 (Study of Collateral Circulation and Related Gene Polymorphism in Patients With Symptomatic Intracranial Anterior Circulation Aortic Occlusion), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04091412 phase4unknown statusnot on this map

Study of Collateral Circulation and Related Gene Polymorphism in Patients With Symptomatic Intracranial Anterior Circulation Aortic Occlusion

TypeinterventionalSponsorThe Second Hospital of Hebei Medical UniversityRan2019 to 2020Enrolled500ConditionsCollateral Circulation, Large-artery Occlusion, Cerebral InfarctionArmsButylphthalide Soft Capsules
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kun ZhangDepartment of Neurology The First Hospital of Hebei Medical University Shijiazhuang China.
Luji LiuDepartment of Neurology The Second Hospital of Hebei Medical University Shijiazhuang China.
Tong LiDepartment of Neurology The First Hospital of Hebei Medical University Shijiazhuang China.
Rui WangDepartment of Neurology The First Hospital of Hebei Medical University Shijiazhuang China.
Kailin BuDepartment of Neurology The First Hospital of Hebei Medical University Shijiazhuang China.
Pandi ZhaoDepartment of Neurology The First Hospital of Hebei Medical University Shijiazhuang China.
Xiaoyun LiuDepartment of Neurology The First Hospital of Hebei Medical University Shijiazhuang China.ORCID 0009-0003-8604-904X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntracranial anterior circulation large artery occlusion (AC-LAO) is a predominant cause of ischemic stroke. Although collateral circulation plays a critical role in stroke outcomes, the genetic and environmental factors affecting collateral development are not fully understood. This study aimed to elucidate the associations between METHODS AND

resultsWe recruited 449 patients with anterior circulation large artery occlusion with cerebral infarction. Collateral circulation was assessed using single-phase computed tomography angiography, and stroke outcomes were evaluated at 1 month and 1 year using the modified Rankin Scale. A subset of 180 patients underwent genetic analysis for

conclusionsCollateral circulation, high-density lipoprotein levels, REGISTRATION: URL: https://www.ClinicalTrials.gov; Unique Identifier: NCT04091412.

Indexed as

Arterial Occlusive DiseasesCerebrovascular CirculationCollateral CirculationIschemic StrokePolymorphism, Single NucleotideAgedCerebral AngiographyComputed Tomography AngiographyFemaleHumansMaleMiddle AgedPrognosisRisk FactorsTime Factorscollateral circulationHDLintracranial anterior circulation large artery occlusionprognosisRabep2 gene polymorphism

Identifiers

PMID40207533
PMCPMC12132831

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.