ArticleJournal of the American Heart Association2025
Blood Pressure, Cardiometabolic Traits, and Cardiovascular Events in Women With Uterine Fibroids: A Genetic Correlation and Mendelian Randomization Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The association of triglyceride-glucose index and uric acid-high-density lipoprotein cholesterol ratio with the risk of uterine fibroids: a real-world analysis based on health examination data.Journal of health, population, and nutrition · 2026Article
- Association between uterine fibroids and hypertension among women of reproductive age in Eastern Sudan: a matched case-control study.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUterine fibroids (UFs) are understudied uterus neoplasms, mainly affecting women of reproductive age and often leading to hysterectomy. Clinical series suggest impaired cardiometabolic features in UFs. We investigated potential genetic links between blood pressure (BP), several cardiometabolic traits, and UFs. METHODS AND
resultsWe used summary statistics of genome-wide association studies for UFs and 18 traits related to BP, obesity, lipids, and main vascular diseases. We applied linkage disequilibrium score regression to estimate genetic correlations and Genome-Wide Complex Trait Analysis-multitrait-based conditional and joint analysis to perform adjusted correlations. Univariate and bidirectional Mendelian randomization verified potential causal associations with UFs. We found UFs to significantly correlate with systolic BP (genetic correlation coefficient [r
conclusionsOur study shows that UFs share substantial genetic basis with traits related to BP, obesity, diabetes, and migraine, a predominantly female vascular disease. We provide Mendelian randomization-based evidence for central obesity, visceral fat traits, and sex-steroid bioavailability as relevant risk factors for UFs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.