Evidence map›Paper›PMID 40207498›Full record

ArticleRNA biology2025

Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is altered in striated muscle diseases.

Gabrielle M Gentile, R Eric Blue, Grant A Goda, Bryan B Guzman, Rachel A Szymanski, Eunice Y Lee, Nichlas M Engels, Emma R Hinkle, Hannah J Wiedner, Aubriana N Bishop and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gabrielle M GentileDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
R Eric BlueDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Grant A GodaDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Bryan B GuzmanDepartment of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Rachel A SzymanskiCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Eunice Y LeeDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nichlas M EngelsDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Emma R HinkleDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Hannah J WiednerDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Aubriana N BishopDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jonathan T HarrisonDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Hua ZhangDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Xander H T WehrensCardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA.
Daniel DominguezDepartment of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jimena GiudiceDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-3330-7784

Funding

UNC Initiative for Maximizing Student DevelopmentR25GM055336 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COOK, JEANETTE GOWEN, KASH, THOMAS L. · 1996 to 2023
$12.1M
Pre-doctoral Training Program in Integrative Vascular BiologyT32HL069768 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christopher P. Mack · 2002 to 2026
$9.7M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Targeting the Pial Collateral Circulation for Mitigation of Cerebral IschemiaR01NS083633 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZHANG, HUA · 2013 to 2023
$4.5M
Predoctoral Training in the Pharmacological SciencesT32GM135095 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Mauro Calabrese, Michael James Emanuele · 2020 to 2026
$3.6M
Protein Disorder as a Modifier of RNA Binding and RegulationR35GM142864 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel Issac Dominguez · 2021 to 2026
$2.5M
Junctophilin-2 cleavage in ischemic heart diseaseR01HL153350 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2021 to 2024
$2.3M
Role of Nucleoside-Diphosphate Kinase Signaling in Atrial FibrillationR01HL160992 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2023 to 2026
$2.1M
Equipment -NEON transfection equipmentR01GM130866 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GIUDICE, JIMENA · 2019 to 2023
$1.6M
Training in Mechanistic, Interdisciplinary Studies of Biological SystemsT32GM119999 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAMSDEN, DALE A · 2017 to 2021
$1.2M
When alternative splicing meets cytoskeleton organization, local translation, and transcription regulationR35GM152426 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jimena Giudice · 2024 to 2026
$1.2M
Educational Pathways to increase Diversity in Genomics (EDGE) at UNC Chapel HillR25HG012219 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BERG, JONATHAN S, IDERAABDULLAH, FOLAMI · 2022 to 2025
$1.1M
NHGRI NIH HHS R25 HG012219NHLBI NIH HHS F31 HL170617NHLBI NIH HHS R01 HL153350NHLBI NIH HHS R01 HL160992NHLBI NIH HHS T32 HL069768NIAMS NIH HHS F31 AR077381NIGMS NIH HHS R01 GM130866NIGMS NIH HHS R25 GM055336NIGMS NIH HHS R35 GM142864NIGMS NIH HHS R35 GM152426NIGMS NIH HHS T32 GM007092NIGMS NIH HHS T32 GM119999NIGMS NIH HHS T32 GM135095NINDS NIH HHS R01 NS083633
6 · The paper itself

Abstract

The reprogramming of alternative splicing networks during development is a hallmark of tissue maturation and identity. Alternative splicing of microexons (small, genomic regions ≤ 51 nucleotides) functionally regulate protein-protein interactions in the brain and is altered in several neuronal diseases. However, little is known about the regulation and function of alternatively spliced microexons in striated muscle. Here, we investigated alternative splicing of a microexon in the synaptosome-associated protein 23 (

Indexed as

Alternative SplicingExonsMuscular DiseasesQc-SNARE ProteinsRNA-Binding ProteinsRNA Splicing FactorsVesicular Transport ProteinsAnimalsHumansMiceMuscle, SkeletalMuscle, StriatedOrgan SpecificityRepressor ProteinsQc-SNARE ProteinsQk protein, mouseRBFOX2 protein, humanRbfox2 protein, mouseRepressor ProteinsRNA-Binding ProteinsRNA Splicing FactorsVesicular Transport Proteinsalternative splicingMicroexonRNA-binding proteinsSnap23striated muscle

Identifiers

PMID40207498
PMCPMC12064062

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.