Evidence map›Paper›PMID 40207450›Full record

ArticleCNS spectrums2025

Which panic-agoraphobic symptoms could be associated with the presence of autistic traits among patients with panic disorder?

Barbara Carpita, Chiara Bonelli, Francesca Parri, Gianluca Cerofolini, Cristiana Pronestì, Benedetta Nardi, Diego Laureti, Gabriele Massimetti, Ivan Mirko Cremone, Stefano Pini and 2 more

Abstract read
In one paragraph

Article in CNS spectrums, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Barbara CarpitaDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0002-2806-6736
Chiara BonelliDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0002-9781-0071
Francesca ParriDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Gianluca CerofoliniDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Cristiana PronestìDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Benedetta NardiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0001-5437-7178
Diego LauretiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Gabriele MassimettiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Ivan Mirko CremoneDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Stefano PiniDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Andrea FiorilloDepartment of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Liliana Dell'OssoDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePanic disorder (PD) is a psychopathological condition characterized by short-lived anxiety attacks in association with several physical symptoms, followed by the fear of other attacks' possible occurrence or their consequences and avoidance behaviors. Recent literature highlighted a significant correlation between autism spectrum disorder (ASD) and anxiety disorder. To date, the specific association between PD and autistic traits (ATs) remains to be clarified. This study aimed to investigate the presence of an autism spectrum in patients with PD, specifically focusing on the presence of possible factors associated with these conditions.

methodsThe study recruited 112 subjects: 55 subjects with a clinical diagnosis of PD and 57 healthy controls (HCs). All participants were evaluated with the Panic Agoraphobic Spectrum-Short Version (PAS-SV) and the Adult Autism Subthreshold Spectrum (AdAS Spectrum) questionnaire.

resultsResults outlined a significant correlation between agoraphobic-panic symptoms and autism spectrum, with significantly positive correlations of all AdAS Spectrum domain scores, as well as its total score with all PAS-SV domains as well as with its total score. Moreover, atypical panic symptoms, and anxious expectation, and maladaptive behaviors were factors associated with a possible underlying presence of higher AT in PD subjects.

conclusionsOur findings support the association between the panic-agoraphobic dimension and ASD. Indeed, increased reactions to stressful life events due to autistic altered sensory reactivity may increase fears responses such as anxious manifestations and maladaptive behaviors.

Indexed as

AgoraphobiaAutism Spectrum DisorderPanic DisorderAdultFemaleHumansMaleMiddle AgedYoung Adultagoraphobic disorderautism spectrum disorderautistic traitspanic-agoraphobic symptomspanic disorder

Identifiers

PMID40207450
PMCPMC13287818

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.