Evidence map›Paper›PMID 40207408›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Selected social and lifestyle correlates of brain health markers: the Cross-Cohort Collaboration Consortium.

Leslie Grasset, Joshua C Bis, Stefan Frenzel, Daniel Kojis, Jeannette Simino, Amber Yaqub, Alexa Beiser, Claudine Berr, Jan Bressler, Robin Bülow and 24 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Selected social and lifestyle correlates of brain health markers: the Cross-Cohort Collaboration Consortium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
  2. Article
  3. Article
  4. Lifestyle medicine in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  5. Article
  6. Article
  7. Objective physical activity and Alzheimer's disease burden in the population-based Rotterdam Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Leslie GrassetUniversity Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France.ORCID 0000-0003-2812-0103
Joshua C BisCardiovascular Health Research Unit, Department of Radiology & Nuclear Medicine, Erasmus University of Washington, Seattle, Washington, USA.
Stefan FrenzelDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Daniel KojisThe Framingham Heart Study, Framingham, Massachusetts, USA.
Jeannette SiminoDepartment of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Amber YaqubDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Alexa BeiserThe Framingham Heart Study, Framingham, Massachusetts, USA.
Claudine BerrINM, Univ Montpellier, INSERM, Montpellier, France.
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Robin BülowInstitute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Charles S DeCarliDepartment of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, California, USA.
Alison E FohnerDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Laura B HarringtonKaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, Washington, USA.
Catherine HelmerUniversity Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Oscar L LopezDepartment of Neurology and psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
W T LongstrethDepartments of Neurology and Epidemiology, University of Washington, Seattle, Washington, USA.
Julia NeitzelDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Michelle C OddenDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Palo Alto, California, USA.
Priya PaltaDepartment of Neurology, University of North Carolina, Chapel Hill, North Carolina, USA.
Carsten O SchmidtInstitute for Community Medicine, University Medicine of Greifswald, Greifswald, Germany.
Rajesh TalluriDepartment of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Meike W VernooijDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Henry VölzkeInstitute for Community Medicine, University Medicine of Greifswald, Greifswald, Germany.
Trudy VoortmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Quest WhalenDepartment of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Katharina WittfeldDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Thomas H MosleyMemory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, Washington, USA.
Frank J WoltersDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Sudha SeshadriThe Framingham Heart Study, Framingham, Massachusetts, USA.
Carole DufouilUniversity Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France.

Funding

CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)RF1AG059421 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2018 to 2018
$6.1M
Infrastructure for mentored access to CHS data and specimensR01HL172803 · NHLBI · UNIVERSITY OF WASHINGTON · PI James S Floyd, Michelle Christina Odden · 2025 to 2026
$2.7M
Alzheimer NederlandNHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL172803NIA NIH HHS RF1 AG059421Stichting Erasmus Trustfonds 97030.2021.101.430/057/RBZonMW Memorabel 10510032120005ZonMW Memorabel 73305095005
6 · The paper itself

Abstract

introductionTo investigate the associations of education level, marital status, and physical activity with dementia risk and brain MRI markers.

methodsData from six community-based samples from the Cross-Cohort Collaboration Consortium were analyzed. Self-reported education level, marital status, and physical activity at age 60 to 75 years were harmonized. Subsamples of participants with brain MRI markers at time of exposure were selected. Associations with dementia risk and cross-sectional MRI markers were meta-analyzed.

resultsHigher education level was associated with lower dementia risk (hazard ratio [HR] = 0.65, 95% confidence interval [CI] = 0.59; 0.72 vs low level) but not significantly with brain MRI markers. Compared with being unmarried, being married was only associated with higher total brain and hippocampal volumes. Being physically active was associated with lower dementia risk (HR = 0.73, 95% CI = 0.52; 1.04), as well as larger total brain volume and smaller white matter hyperintensity volume. DISCUSSION: This study provides further evidence regarding the contribution of education level and physical activity to dementia resilience. HIGHLIGHTS: Education level, marital status, and physical activity are thought to contribute to resilience against ADRD. We used random-effects meta-analysis to summarize results from six community-based samples from the CCC. In this cross-cohort meta-analysis, higher education level and being physically active were associated with lower risk of dementia. In cross-sectional analyses, being married was associated with larger TBV and HV, while being physically active was associated with larger TBV and lower WMHV.

Indexed as

BrainDementiaExerciseLife StyleAgedCohort StudiesCross-Sectional StudiesEducational StatusFemaleHumansMagnetic Resonance ImagingMaleMarital StatusMiddle AgedRisk Factorscohortsdementiameta‐analysisMRIresilience

Identifiers

PMID40207408
PMCPMC11982914

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.