Trial reportFrontiers in immunology2025
Safety and immunogenicity of GamEvac-Combi, a heterologous rVSV- and rAd5-vectored Ebola vaccine: a randomized controlled multicenter clinical trial in the Republic of Guinea and Russia.
Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph
Trial report in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03072030 (01 - GamEvac-Combi-2016 " International Multicenter Study of the Immunogenicity of Medicinal Product GamEvac-Combi - Combined Vector-Based Vaccine Against Ebola Virus Disease, 0.5 ml+0.5 ml/Dose "), which is not on this map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
01 - GamEvac-Combi-2016 " International Multicenter Study of the Immunogenicity of Medicinal Product GamEvac-Combi - Combined Vector-Based Vaccine Against Ebola Virus Disease, 0.5 ml+0.5 ml/Dose "
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
71 authors.
Denis Y Logunov *National Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Inna V Dolzhikova *National Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Mamadou Y BoiroResearch Institute of Applied Biology of Guinea, Kindia, Guinea.
Anna V KovyrshinaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Alina S DzharullaevaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Alina S ErokhovaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Daria M GrousovaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Amir I TukhvatulinNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Fatima M IzhaevaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Yana V SimakovaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Maria K OrdzhonikidzeNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Nadezhda L LubenetsNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Olga V ZubkovaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Dmitrii V ScheblyakovNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Ilias B EsmagambetovNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Maksim M ShmarovNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Alexander S SemikhinNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Natalia M TukhvatulinaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Dmitrii N ShcherbininNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Irina L TutykhinaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Georgiy S ProkhorovNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Alexander A KhovaevNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Tatiana N DemidovaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Nikolai A MalishevNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Liliya N MerkulovaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Olga L VoroninaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Irina T FedyakinaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Lidiya B KistenevaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Lyudmila V KolobukhinaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Dmitry V MishinNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Aleksandr L ElakovNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Ekaterina I ErmolovaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Kirill G KrasnoslobodtsevNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Viktor F LarichevNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Irina S KruzhkovaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Egor M BurmistrovNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Anna B SheremetNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Elizaveta A TokarskayaNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Alexander V GromovNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Dmitrii A ReshetnikovNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Aleksandr I FisunFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Bogdan N KotivFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Dmitrii V OvchinnikovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Evgenii V IvchenkoFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Konstantin V ZhdanovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Sergei M ZakharenkoFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Aleksandr N SolovevFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Andrei M IvanovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Vitalii S SukachevFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Roman V GudkovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Oleg V MaltsevFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Ilnur A GabdrakhmanovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Anton V BarsukovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Vladislav V VashchenkovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Nikolai I DemianenkoFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Sergei B IgnatevFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Konstantin V AsiamovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Nikolai N KirichenkoFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Andrei V LiubimovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Igor I VolkovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Evgenii V KriukovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Nikolai K BazarnovFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Viktoriia A KolodiazhnaiaFederal State Budgetary Military Educational Institution Of Higher Education «Military Medical Academy named after Sergey Mironovich (S.M.) Kirov» of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
Elena V KolomoetsMedical Service Compagnie des Bauxites de Kindia (CBK) RUSAL, Research Center for Epidemiology, Microbiology and Medical Care, Centre de Recherche en épidémiologie, microbiologie et de soins médicaux (CREMS) (Pastori), Kindia, Guinea.
Svetlana I Syromyatnikova48 Central Research Institute, Ministry of Defense, Sergiev Posad, Russia.
Dmitry E Chifanov48 Central Research Institute, Ministry of Defense, Sergiev Posad, Russia.
Alexander F Andrus48 Central Research Institute, Ministry of Defense, Sergiev Posad, Russia.
Dmitry A Kutaev48 Central Research Institute, Ministry of Defense, Sergiev Posad, Russia.
Sergei V Borisevich48 Central Research Institute, Ministry of Defense, Sergiev Posad, Russia.
Boris S NaroditskyNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Alexander L GintsburgNational Research Centre of Epidemiology and Microbiology named after Honorary Academician Nikolay Fyodorovich (N. F.) Gamaleya, Ministry of Health of Russian Federation, Moscow, Russia.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ebola virus disease (EVD) is one of the most dangerous and lethal diseases affecting humans. There are several licensed vaccines against EVD, but it remains one of the priority diseases for research and development of effective vaccines. Methods: A double-blind randomized placebo-controlled trial was performed to evaluate safety and immunogenicity of rVSV- and rAd5-vectored vaccine GamEvac-Combi in healthy adults of both sexes between 18 and 60 years. Safety and immunogenicity were assessed during the observation period of 12 months. Immunogenicity was assessed with GP-specific ELISA, IFN-γ ELISA, and plaque pseudoneutralization assay. Results: Vaccinated participants showed marked GP-specific IFN-γ response at day 28 and neutralizing response at day 42 (GMT = 32.6, seroconversion rate 96.3%). GP-specific IgG antibody levels in vaccinated participants peaked at day 42 (GMT = 9345) and persisted for a year after vaccination (GMT = 650). Conclusion: The vaccine showed favorable safety profile and induced robust cell-mediated immune response and strong humoral immune response that lasts at least for a year from the start of vaccination. Clinical trial registration: ClinicalTrials.gov, identifier NCT03072030; Pan African Clinical Trial Registry, identifier PACTR201702002053400.
Indexed as
Ebola VaccinesEbolavirusHemorrhagic Fever, EbolaImmunogenicity, VaccineAdolescentAdultAntibodies, NeutralizingAntibodies, ViralDouble-Blind MethodFemaleGuineaHumansImmunity, HumoralMaleMiddle AgedRussiaAntibodies, NeutralizingAntibodies, ViralEbola Vaccinesclinical trialsEbola vaccineEVDprime-boostrAd5rVSVvector vaccine
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT03072030ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.