ArticleFrontiers in immunology2025
Exploring the possible mechanism of low-dose naloxone exposure improving the immune microenvironment of gastric cancer tumors.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- New Functions of Mitochondrial Dysfunction in Gastric Cancer: From Molecular Processes to Potential Treatments.International journal of molecular sciences · 2026Review
- Crosstalk Between Opioids and the Anti-Tumour Immune Checkpoint Axis.Current oncology (Toronto, Ont.) · 2026Review
- Perioperative local anesthetics as modulators of tumor progression and metastasis.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Gastric cancer, one of the most common cancers of the digestive tract, has high incidence and mortality rates. Until recently, surgery has been the most effective method of treatment for gastric cancer. Surgery, however, inevitably results in dysfunction of the autonomic nervous system, entry of tumor cells into the bloodstream, and immunosuppression during the perioperative period, all of which increase the risk of complications in patients with gastric cancer. Opioid receptors play an important role in the proliferation and secretion of cytotoxic factors by immune cells. Opiate usage inhibits immune cell function, reduces the release of cytotoxic factors, and enables tumor cells to evade the immune system, thereby increasing the risk of perioperative complications. Opioid antagonists may reverse opioid-mediated immunosuppression in several ways. However, studies on the molecular biology of opioid receptor antagonists in relation to their ability to improve immune function in patients with gastric cancer are limited. Methods: We first analyzed the cancer genome atlas stomach adenocarcinoma (TCGA-STAD) dataset to determine the correlation between changes in immune function and toll-like receptor 4 (TLR4) expression in patients with gastric cancer. A transwell co-culture system was established using CD8 Results: We found that changes in perioperative immune function strongly correlated with TLR4 expression on the surface of immune cells in patients with gastric cancer. Low-dose naloxone (LDN) increased CD8 Conclusion: LDN improved the ability of CD8
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