Evidence map›Paper›PMID 40207165›Full record

ArticleFrontiers in microbiology2025

Isolation, phylogenetics, and characterization of a new PDCoV strain that affects cellular gene expression in human cells.

Xiaozhu Yang, Hanwei Yin, Mengyuan Liu, Xuemei Wang, Tao Song, Aiai Song, Yibo Xi, Ting Zhang, Zilong Sun, Wei Li and 6 more

Erratum issuedAbstract read
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In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Xiaozhu Yang *College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Hanwei Yin *College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Mengyuan LiuCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Xuemei WangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Tao SongCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China.
Aiai SongXianyang Regional Wen's Animal Husbandry Co., Ltd., Xianyang, China.
Yibo XiSchool of Management Shanxi Medical University, Taiyuan, China.
Ting ZhangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Zilong SunCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Wei LiCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Sheng NiuCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Farwa ZainabCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Chenyang WangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Ding ZhangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Haidong WangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Bo YangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Porcine deltacoronavirus (PDCoV) is an enteropathogenic coronavirus that causes acute diarrhea, vomiting, dehydration, and even death in piglets, resulting in serious economic losses to the pork industry worldwide. PDCoV has received much attention owing to its broad host range, including humans, posing a potential threat to public health. However, the prevalence, characteristics, and host cellular gene expression of PDCoV remain poorly understood. Methods: In this study, a new PDCoV strain (CHN/SX-Y/2023, GenBank number PQ373831) was successfully isolated, identified, and subjected to phylogenetic tree and transcriptome analysis in human hepatoma (Huh7) cells following PDCoV infection. Results: The results showed that the CHN/SX-Y/2023 strain belongs to the Chinese lineage and causes cytopathic effects in canonical cell lines (LLC-PK1 and ST cells) and other cell lines (Huh7 and LMH cells). However, HEK-293T, EEC, MDBK, and Vero-CCL81 cells were not found to be susceptible in this study. Based on transcriptome analysis, 1,799 differentially expressed genes (DEGs) were upregulated and 771 were downregulated during PDCoV infection. Discussion: Among the upregulated genes,

Indexed as

Huh7 cellsimmune responsePDCoVphylogenetic treetranscriptome analysis

Identifiers

PMID40207165
PMCPMC11979167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.