Evidence map›Paper›PMID 40207083›Full record

ArticleBiochemistry and biophysics reports2025

Effects of the number of ethylene glycol units on the efficacy of novel complex I inhibitor 9bw.

Kazuaki Sekimoto, Hanaka Kinjo, Mizuki Murakami, Akiko Ohashi, Rei Fukui, Eri Nagasaki-Maeoka, Yoshinori Inagaki, Tadateru Takayama, Kazuhiro Ikeda, Ken-Ichi Takayama and 4 more

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In one paragraph

Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kazuaki SekimotoDepartment of Anatomy, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, 101-8310, Japan.
Hanaka KinjoDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda-ku, Tokyo, 101-8308, Japan.
Mizuki MurakamiDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda-ku, Tokyo, 101-8308, Japan.
Akiko OhashiDepartment of Anatomy, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, 101-8310, Japan.
Rei FukuiDepartment of Pathology, Nihon University School of Dentistry, Chiyoda-ku, 101-8310, Japan.
Eri Nagasaki-MaeokaDepartment of Pediatric Surgery, Jichi Medical University, Saitama Medical Center, Saitama, 330-8503, Japan.
Yoshinori InagakiDivision of General Medicine, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, 173-0032, Japan.
Tadateru TakayamaDivision of General Medicine, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, 173-0032, Japan.
Kazuhiro IkedaDivision of Systems Medicine & Gene Therapy, Saitama Medical University, Hidaka, Saitama, 350-1241, Japan.
Ken-Ichi TakayamaDepartment of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
Satoshi InoueDivision of Systems Medicine & Gene Therapy, Saitama Medical University, Hidaka, Saitama, 350-1241, Japan.
Motonori TsujiInstitute of Molecular Function, 2-105-14, Takasu, Misato-shi, Saitama, 341-0037, Japan.
Joe OtsukiDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda-ku, Tokyo, 101-8308, Japan.
Kyoko FujiwaraDepartment of Anatomy, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, 101-8310, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

4'-Iodobiphenyl nonaethylene glycol ether (9bw) is a novel small molecule, composed of a biphenyl unit and 9 ethylene glycol (EG) units. Recently, we found that 9bw induces apoptosis in cancer cells by inhibiting mitochondrial respiratory complex I (CI) and accordingly reducing cellular ATP level. In addition, 9bw shows little effect on normal cells, suggesting that 9bw is a potential antitumor agent with few adverse effects. However, the exact molecular mechanisms by which 9bw acts on CI are still elusive. To clarify the molecular structure critical for 9bw's function, we tested the function of 9bw analogues on human oral squamous cell carcinoma lines HSC4 and Ca9-22. The analogues were 4-hydroxy-4'-iodobiphenyl (HIOP), I-BP-EG3, I-BP-EG6, and I-BP-EG12 containing 0, 3, 6, and 12 EG units, respectively. Our results demonstrated that I-BP-EG6 and I-BP-EG12 inhibited CI to a similar extent as 9bw, whereas I-BP3 and HIOP showed no effect on CI activity. These observations indicate that the number of EG units is crucial for the activity of 9bw and its analogues. As high-performance liquid chromatography (HPLC) analysis demonstrated that both HIOP and I-BP-EG3 could be incorporated into mitochondria abundantly, the number of EG units probably affects CI inhibitory function of 9bw and its analogues rather than their efficacy to enter cell and mitochondria.

Indexed as

4′-iodobiphenyl9bwEthylene glycolOral squamous cell carcinomaRespiratory complex I

Identifiers

PMID40207083
PMCPMC11979437

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.