ArticleCureus2025
Assessment of the Diagnostic Accuracy of the Modified Hodge Test and Modified Carbapenem Inactivation Method for Identifying Carbapenem Resistance Mechanisms in Klebsiella pneumoniae: A Whole Genome Sequencing-Based Exploratory Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
8 authors.
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Abstract
aimCarbapenem-resistant MATERIAL AND
methodsThis exploratory study consisted of 65 CRKP isolates, which were identified using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) (Bruker Daltonik GmbH, Bremen, Germany). Antimicrobial susceptibility testing was performed using the BD Phoenix system. The test isolates were subjected to MHT and mCIM and later shipped to the Central Research Laboratory (CRL), Bengaluru, India, where they were subjected to polymerase chain reaction (PCR) and whole-genome sequencing (WGS).
resultsPCR detected
conclusionsComprehensive assessment of the diagnostic accuracy of MHT and mCIM using WGS across a broad spectrum of multi-drug-resistant (MDR) organisms should be conducted at multiple centers to produce reliable data that can guide better clinical management of the patients.
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